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Figure 2 | Respiratory Research

Figure 2

From: Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation

Figure 2

Immunohistochemical localization of TNF-α in the lung. No positive staining for TNF-α was observed in the lung tissues collected at 24 hours from sham WT mice (a) and from sham TNF-αR1KO mice (b). On the contrary, tissue sections obtained from WT animals at 4 h (c) and at 24 hours (d) after carrageenan injection demonstrate positive staining for TNF-α mainly localized in the infiltrated inflammatory cells, pneumocytes as well as in vascular wall. In carrageenan-injected TNF-αR1KO mice, no positive staining for TNF-α were observed in the lung tissues collected at 4 h (e) and at 24 hours (f). Similarly, the treatment of WT mice with Etanercept (5 mg/kg administered s.c. 2 h prior carrageenan) visibly and significantly reduced the positive staining for TNF-α in the infiltrated inflammatory cells, pneumocytes as well as in vascular wall in the lung tissues collected at 4 h (g) and at 24 hours (h). Figure is representative of at least 3 experiments performed on different experimental days.

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