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Table 2 Summarized stereological data

From: Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient mice

Parameter D0 D3 D6 D9 WT
V(lung) [cm 3 ] 1.00 (0.06) 0.72 (0.02) 0.82 (0.07) 0.76 (0.1) 0.68 (0.22)
N(alv,lung) [10 6 ] 5.80 (0.52) 7.03 (0.58) 8.51 (1.01) 7.36 (0.58) 8.75 (3.18)
N V (alv/par) [10 3 /mm 3 ] 6.65 (0.58) 10.71 (0.51) 11.17 (0.92) 10.81 (0.95) 14.11 (0.76)†||§**
N (alv) [10 3 μm 3 ] 139.67 (6.87) 79.26 (5.78) 75.66 (5.1) 82.07 (8.19) 59.40 (9.19)†||§**
S(alvepi,lung) [cm 2 ] 597.7 (51.9) 583.3 (66.4) 671.5 (74.1) 592.8 (61.2) 575.3 (157.2)
S V (alvepi/par) [1/cm] 661.8 (46.3) 910.3 (65.7) 881.1 (47.1) 866.6 (38.0) 959.5 (146.3)
V V (air/par) [%] 90.4 (2.3) 86.8 (3.1) 84.2 (3.0) 88.2 (4.1) 83.5 (11.1)
V V (sep/par) [%] 10.4 (0.5) 13.8 (1.7) 13.6 (1.5) 13.4 (1.8) 17.3 (7.2)
(sep) [μm] 3.14 (0.22) 3.04 (0.58) 3.08 (0.46) 3.08 (0.4) 3.5 (0.86)
N(typeII,lung) [10 6 ] 12.57 (1.61) 12.58 (0.76) 11.02 (0.64) 7.29 (0.97)†||§ 7.73 (1.91)†||§
N V (typeII/par) [10 3 /mm 3 ] 13.87 (1.12) 19.74 (1.58) 14.52 (0.62)|| 10.6 (0.59)†||§ 13.15 (3.54)||
N (typeII) [μm 3 ] 467.5 (18.6) 408.97 (36.1) 417.15 (17.5) 418.38 (10.9) 348.5 (28.53)†||§**
V V (lb/typeII) [%] 24.7 (2.5) 23.5 (4.4) 19.7 (1.9) 19.8 (2.1) 15.3 (1)†||§**
V(lb,typeII) [μm 3 ] 114.9 (8.3) 97.0 (25.7) 82.1 (8.7) 82.7 (10.7) 53.2 (6.2)†||§**
V(lb,lung) [mm 3 ] 1.44 (0.19) 1.21 (0.31) 0.9 (0.11) 0.61 (0.14)†||§ 0.42 (0.14)†||§
V (lb) [μm 3 ] 0.93 (0.12) 1.40 (0.35) 0.67 (0.08)†|| 0.78 (0.03)|| 0.48 (0.08)†||§**
  1. Summarized stereological data, grouped into parameters related to parenchymal architecture, to type II cells, and to lamellar bodies. Values are given as mean (SD) of n = 4–5 mice per group. Abbreviations: V = volume, VV = volume density, S = surface area, SV = surface area density, = mean thickness, N = number, NV = numerical density, N = number-weighted mean volume, V = volume-weighted mean volume, par = parenchyma, air = airspace, sep = septal tissue, alvepi = alveolar epithelium, alv = alveoli, typeII = type II cells, lb = lamellar bodies. Statistically significant differences between groups are indicated as: p < 0.05 vs. group D0, || p < 0.05 vs. group D3, § p < 0.05 vs. group D6, ** p < 0.05 vs. group D9.