Table 2 Summarized stereological data
Parameter | D0 | D3 | D6 | D9 | WT |
|---|---|---|---|---|---|
V(lung) [cm 3 ] | 1.00 (0.06) | 0.72 (0.02)†| 0.82 (0.07)†| 0.76 (0.1)†| 0.68 (0.22)†|
N(alv,lung) [10 6 ] | 5.80 (0.52) | 7.03 (0.58)†| 8.51 (1.01)†| 7.36 (0.58)†| 8.75 (3.18) |
N V (alv/par) [10 3 /mm 3 ] | 6.65 (0.58) | 10.71 (0.51)†| 11.17 (0.92)†| 10.81 (0.95)†| 14.11 (0.76)†||§** |
| 139.67 (6.87) | 79.26 (5.78)†| 75.66 (5.1)†| 82.07 (8.19)†| 59.40 (9.19)†||§** |
S(alvepi,lung) [cm 2 ] | 597.7 (51.9) | 583.3 (66.4) | 671.5 (74.1) | 592.8 (61.2) | 575.3 (157.2) |
S V (alvepi/par) [1/cm] | 661.8 (46.3) | 910.3 (65.7)†| 881.1 (47.1)†| 866.6 (38.0)†| 959.5 (146.3)†|
V V (air/par) [%] | 90.4 (2.3) | 86.8 (3.1) | 84.2 (3.0)†| 88.2 (4.1) | 83.5 (11.1) |
V V (sep/par) [%] | 10.4 (0.5) | 13.8 (1.7)†| 13.6 (1.5)†| 13.4 (1.8)†| 17.3 (7.2)†|
| 3.14 (0.22) | 3.04 (0.58) | 3.08 (0.46) | 3.08 (0.4) | 3.5 (0.86) |
N(typeII,lung) [10 6 ] | 12.57 (1.61) | 12.58 (0.76) | 11.02 (0.64)†| 7.29 (0.97)†||§ | 7.73 (1.91)†||§ |
N V (typeII/par) [10 3 /mm 3 ] | 13.87 (1.12) | 19.74 (1.58)†| 14.52 (0.62)|| | 10.6 (0.59)†||§ | 13.15 (3.54)|| |
| 467.5 (18.6) | 408.97 (36.1)†| 417.15 (17.5)†| 418.38 (10.9)†| 348.5 (28.53)†||§** |
V V (lb/typeII) [%] | 24.7 (2.5) | 23.5 (4.4) | 19.7 (1.9)†| 19.8 (2.1)†| 15.3 (1)†||§** |
V(lb,typeII) [μm 3 ] | 114.9 (8.3) | 97.0 (25.7) | 82.1 (8.7)†| 82.7 (10.7)†| 53.2 (6.2)†||§** |
V(lb,lung) [mm 3 ] | 1.44 (0.19) | 1.21 (0.31) | 0.9 (0.11)†| 0.61 (0.14)†||§ | 0.42 (0.14)†||§ |
| 0.93 (0.12) | 1.40 (0.35) | 0.67 (0.08)†|| | 0.78 (0.03)|| | 0.48 (0.08)†||§** |
N
(alv) [10
3
μm
3
]
(sep) [μm]- Summarized stereological data, grouped into parameters related to parenchymal architecture, to type II cells, and to lamellar bodies. Values are given as mean (SD) of n = 4–5 mice per group. Abbreviations: V = volume, VV = volume density, S = surface area, SV = surface area density,
= mean thickness, N = number, NV = numerical density, 
N = number-weighted mean volume,
V = volume-weighted mean volume, par = parenchyma, air = airspace, sep = septal tissue, alvepi = alveolar epithelium, alv = alveoli, typeII = type II cells, lb = lamellar bodies. Statistically significant differences between groups are indicated as: †p < 0.05 vs. group D0, || p < 0.05 vs. group D3, § p < 0.05 vs. group D6, ** p < 0.05 vs. group D9.