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Table 2 Summarized stereological data

From: Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient mice

Parameter

D0

D3

D6

D9

WT

V(lung) [cm 3 ]

1.00 (0.06)

0.72 (0.02)

0.82 (0.07)

0.76 (0.1)

0.68 (0.22)

N(alv,lung) [10 6 ]

5.80 (0.52)

7.03 (0.58)

8.51 (1.01)

7.36 (0.58)

8.75 (3.18)

N V (alv/par) [10 3 /mm 3 ]

6.65 (0.58)

10.71 (0.51)

11.17 (0.92)

10.81 (0.95)

14.11 (0.76)†||§**

N (alv) [10 3 μm 3 ]

139.67 (6.87)

79.26 (5.78)

75.66 (5.1)

82.07 (8.19)

59.40 (9.19)†||§**

S(alvepi,lung) [cm 2 ]

597.7 (51.9)

583.3 (66.4)

671.5 (74.1)

592.8 (61.2)

575.3 (157.2)

S V (alvepi/par) [1/cm]

661.8 (46.3)

910.3 (65.7)

881.1 (47.1)

866.6 (38.0)

959.5 (146.3)

V V (air/par) [%]

90.4 (2.3)

86.8 (3.1)

84.2 (3.0)

88.2 (4.1)

83.5 (11.1)

V V (sep/par) [%]

10.4 (0.5)

13.8 (1.7)

13.6 (1.5)

13.4 (1.8)

17.3 (7.2)

(sep) [μm]

3.14 (0.22)

3.04 (0.58)

3.08 (0.46)

3.08 (0.4)

3.5 (0.86)

N(typeII,lung) [10 6 ]

12.57 (1.61)

12.58 (0.76)

11.02 (0.64)

7.29 (0.97)†||§

7.73 (1.91)†||§

N V (typeII/par) [10 3 /mm 3 ]

13.87 (1.12)

19.74 (1.58)

14.52 (0.62)||

10.6 (0.59)†||§

13.15 (3.54)||

N (typeII) [μm 3 ]

467.5 (18.6)

408.97 (36.1)

417.15 (17.5)

418.38 (10.9)

348.5 (28.53)†||§**

V V (lb/typeII) [%]

24.7 (2.5)

23.5 (4.4)

19.7 (1.9)

19.8 (2.1)

15.3 (1)†||§**

V(lb,typeII) [μm 3 ]

114.9 (8.3)

97.0 (25.7)

82.1 (8.7)

82.7 (10.7)

53.2 (6.2)†||§**

V(lb,lung) [mm 3 ]

1.44 (0.19)

1.21 (0.31)

0.9 (0.11)

0.61 (0.14)†||§

0.42 (0.14)†||§

V (lb) [μm 3 ]

0.93 (0.12)

1.40 (0.35)

0.67 (0.08)†||

0.78 (0.03)||

0.48 (0.08)†||§**

  1. Summarized stereological data, grouped into parameters related to parenchymal architecture, to type II cells, and to lamellar bodies. Values are given as mean (SD) of n = 4–5 mice per group. Abbreviations: V = volume, VV = volume density, S = surface area, SV = surface area density, = mean thickness, N = number, NV = numerical density, N = number-weighted mean volume, V = volume-weighted mean volume, par = parenchyma, air = airspace, sep = septal tissue, alvepi = alveolar epithelium, alv = alveoli, typeII = type II cells, lb = lamellar bodies. Statistically significant differences between groups are indicated as: p < 0.05 vs. group D0, || p < 0.05 vs. group D3, § p < 0.05 vs. group D6, ** p < 0.05 vs. group D9.