Body composition and functional limitation in COPD

Respiratory Research

Table 6 Independent influence of lean and fat mass on functional limitation in COPD

Measure of body composition	Self-reported functional limitation	Six Minute Walk Test	SPPB Summary Performance Score
	OR (95% CI)	Mean (95% CI)	Mean (95% CI)
MEN (n = 143)
Lean mass_resid	1.0 (0.89 to 1.12)	5 (-10 to 20)	0.018 (-0.05 to 0.09)
Fat mass	1.06 (0.99 to 1.13)*	-13 (-21 to -5)	-0.025 (-0.062 to 0.013)
SAD_resid	0.95 (0.76 to 1.19)	-38 (-68 to -7)	-0.097 (-0.24 to 0.043)
WOMEN (n = 212)
Lean mass_resid	1.005 (0.91 to 1.12)	-14 (-31 to 3)	0.034 (-0.044 to 0.11)
Fat mass	1.04 (1.017 to 1.067)	-11 (-15 to -8)	-0.037 (-0.053 to -0.020)
SAD_resid	1.09 (0.94 to 1.26)	-16 (-39 to 7)	-0.012 (-0.12 to 0.097)

Logistic or linear multivariate regression including variables shown plus age, FEV₁/FVC, height, race, education, and smoking. *p = 0.077
Results are for 1 kg increment in lean or fat mass OR per 1 cm increment in SAD
Lean mass_resid = residual variable for lean mass removing the contribution of fat mass and height;
SAD_resid = residual variable for sagittal abdominal diameter removing the contribution of lean mass and fat mass (see Methods)

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