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Table 6 Independent influence of lean and fat mass on functional limitation in COPD

From: Body composition and functional limitation in COPD

Measure of body composition Self-reported functional limitation Six Minute Walk Test SPPB Summary Performance Score
  OR (95% CI) Mean (95% CI) Mean (95% CI)
MEN (n = 143)    
Lean massresid 1.0 (0.89 to 1.12) 5 (-10 to 20) 0.018 (-0.05 to 0.09)
Fat mass 1.06 (0.99 to 1.13)* -13 (-21 to -5) -0.025 (-0.062 to 0.013)
SADresid 0.95 (0.76 to 1.19) -38 (-68 to -7) -0.097 (-0.24 to 0.043)
WOMEN (n = 212)    
Lean massresid 1.005 (0.91 to 1.12) -14 (-31 to 3) 0.034 (-0.044 to 0.11)
Fat mass 1.04 (1.017 to 1.067) -11 (-15 to -8) -0.037 (-0.053 to -0.020)
SADresid 1.09 (0.94 to 1.26) -16 (-39 to 7) -0.012 (-0.12 to 0.097)
  1. Logistic or linear multivariate regression including variables shown plus age, FEV1/FVC, height, race, education, and smoking. *p = 0.077
  2. Results are for 1 kg increment in lean or fat mass OR per 1 cm increment in SAD
  3. Lean massresid = residual variable for lean mass removing the contribution of fat mass and height;
  4. SADresid = residual variable for sagittal abdominal diameter removing the contribution of lean mass and fat mass (see Methods)