Body composition and functional limitation in COPD

Respiratory Research

Table 5 The influence of body composition on physical performance among patients with COPD

Measure of body composition	Standing balance score	Walking speed score	Chair stand score	Summary performance score
MEN (n = 143)
Lean/fat ratio	0.007 (-0.034 to 0.049)	0.020 (-0.021 to 0.060)	0.038 (-0.05 to 0.13)	0.65 (-0.070 to 0.20)
SAD	-0.015 (-0.035 to 0.006)	-0.019 (-0.039 to 0.0015)*	-0.033 (-0.076 to 0.011)	-0.067 (-0.13 to 0.00)
BMI
Normal weight	Referent	Referent	Referent	Referent
Overweight	0.060 (-0.22 to 0.34)	-0.081 (-0.36 to 0.20)	0.45 (-0.14 to 1.04)	0.43 (-0.48 to 1.35)
Obese	-0.13 (-0.38 to 0.11)	-0.14 (-0.38 to 0.11)	-0.008 (-0.053 to 0.51)	-0.28 (-1.08 to 0.52)
WOMEN (n = 212)
Lean/fat ratio	0.070 (-0.023 to 0.16)	0.10 (-0.007 to 0.43)*	0.35 (0.17 to 1.05)	0.52 (0.24 to 0.80)
SAD	-0.011(-0.028 to 0.006)	-0.033 (-0.052 to -0.14)	-0.053 (-0.085 to -0.021)	-0.097 (-0.015 to -0.047)
BMI
Normal weight	Referent	Referent	Referent	Referent
Overweight	-0.003 (-0.25 to 0.24)	-0.016 (-0.30 to 0.27)	-0.082 (-0.55 to 0.39)	-0.10 (-0.84 to 0.64)
Obese	-0.029 (-0.23 to 0.17)	-0.38 (-0.61 to -0.15)	-0.60 (-0.98 to -0.22)	-1.00 (-1.61 to -0.40)

All results are mean score (95% CI) from multivariate linear regression controlling for age, height, FEV1/FVC, race, education, and smoking history.
Results are from separate multivariate linear regression of each score regressed on body composition measures plus covariates.
Boldface when p < 0.05 *p = 0.07
Each Short Physical Performance subscale score ranges from 0–4, with higher scores reflecting more favorable performance. Summary performance score is sum of each subscale score and ranges from 0–12.
Lean/fat ratio = derived from bioelectrical impedance. Results are expressed per 0.50 increment in the ratio.
SAD = sagittal abdominal diameter, an estimate of visceral fat. Results are expressed per 1 cm increment.
BMI = body mass index, an estimate of adiposity; normal weight (18.5 to 24.9 kg/m²) overweight = 25.0 to 29.9 kg/m², obese = 30.0 kg/m² or greater; only 9/355 (2.5%) of subjects were in underweight category (< 18.5 kg/m²) so these were included in the normal weight group

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