Body composition and functional limitation in COPD

Respiratory Research

Table 3 Body composition and the risk of self-reported functional limitation among 355 patients with COPD

Measure of body composition	Age adjusted	Age, height, FEV₁/FVC adjusted	Age, height, FEV₁/FVC, race, education, and smoking adjusted
	OR (95% CI)	OR (95% CI)	OR (95% CI)
MEN (n = 143)
Lean/fat ratio	1.02 (0.87 to 1.20)	0.98 (0.82 to 1.16)	0.99 (0.83 to 1.18)
SAD	1.07 (0.99 to 1316)	1.10 (1.0 to 1.20)	1.09 (0.99 to 1.21)
BMI
Normal weight	Referent	Referent	Referent
Overweight	0.36 (0.10 to 1.27)	0.42 (0.11 to 1.56)	0.46 (0.12 to 1.81)
Obese	0.92 (0.38 to 2.24)	1.16 (0.44 to 3.03)	1.12 (0.39 to 3.20)
WOMEN (n = 212)
Lean/fat ratio	0.49 (0.32 to 0.75)	0.44 (0.27 to 0.70)	0.45 (0.28 to 0.74)
SAD	1.13 (1.06 to 1.21)	1.15 (1.07 to 1.24)	1.15 (1.07 to 1.23)
BMI
Normal weight	Referent	Referent	Referent
Overweight	0.79 (0.28 to 2.24)	0.82 (0.28 to 2.37)	0.74 (0.25 to 2.18)
Obese	3.0 (1.45 to 6.23)	3.77 (1.70 to 8.37)	3.50 (1.53 to 8.01)

Results are from separate multivariate logistic regression of self-reported functional limitation regressed on body composition measures plus covariates.
Lean/fat ratio = derived from bioelectrical impedance. Odds ratios are expressed per 0.50 increment in the ratio.
SAD = sagittal abdominal diameter, an estimate of visceral fat. Odds ratios are expressed per 1 cm increment.
BMI = body mass index, an estimate of adiposity; normal weight (18.5 to 24.9 kg/m²) overweight = 25.0 to 29.9 kg/m², obese = 30.0 kg/m² or greater; only 9/355 (2.5%) of subjects were in underweight category (< 18.5 kg/m²) so these were included in the normal weight group.

ISSN: 1465-993X