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Table 5 Total amount [nmol/vial] of drug related compounds in human lung tissue slices

From: In vitro metabolism of beclomethasone dipropionate, budesonide, ciclesonide, and fluticasone propionate in human lung precision-cut tissue slices

 

Incubation time [h]

Parent compound

Active compound

Fatty acid esters

Inactive metabolite

Beclomethasone

2

2.19 ± 0.83

7.88 ± 2.21

0.90 ± 0.46

0.38 ± 0.06

dipropionate 2

6

0.72 ± 0.46

7.78 ± 3.80

0.50 ± 0.40

1.89 ± 0.49

 

24

-

2.73 ± 2.22

0.87 ± 0.96

5.72 ± 1.20

Budesonide 1

2

7.32 ± 0.99

3.17 ± 2.00

-

 

6

8.41 ± 2.15

5.39 ± 4.03

-

 

24

9.04 ± 1.14

8.91 ± 5.15

-

Ciclesonide

2

6.46 ± 0.92

0.76 ± 0.2

0.40 ± 0.20

-

 

6

8.86 ± 1.68

2.17 ± 0.51

1.10 ± 0.73

-

 

24

9.53 ± 1.70

7.61 ± 1.31

7.29 ± 3.79

-

Fluticasone 1

2

8.42 ± 1.26

-

-

propionate

6

8.62 ± 2.20

-

-

 

24

9.51 ± 2.22

-

-

  1. Data are presented as mean ± standard deviation (n = 9).
  2. 1Parent and active compound.
  3. 2The active compound of BDP may be overestimated as inactive 21-BMP may be included.
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Respiratory Research

ISSN: 1465-993X

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