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Table 2 Pros and cons of noninvasive barometric whole-body plethysmography

From: Invasive and noninvasive methods for studying pulmonary function in mice

pros cons
• minimal restraint of the animal • enhanced pause as an empirically derived value with unclear physiological relevance
  • influenced by a number of factors unrelated to bronchoconstriction
  • potential to overestimate or underestimate the real degree of airway responsiveness
  • data need to be confirmed by invasive methodology