Skip to main content
Figure 4 | Respiratory Research

Figure 4

From: Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus

Figure 4

Characterization and functional analysis of BAL cells after HMPV or RSV infection. Percentage of (A) CD8+, (B) CD4+, and (C) IFN-γ-producing CD8+ cells of total BAL lymphocytes as determined by FACS analysis of BAL cells from HMPV- or RSV-infected BALB/c mice. * P < 0.05, ** P < 0.01 (n = 6–11). (D) Percentage of NK cells (DX5+/CD3-) of total BAL lymphocytes in the BAL of HMPV- or RSV-infected BALB/C mice (2 × 105 PFU/mouse), and (E) NK cell-mediated cytotoxicity in mice infected with 2 × 105 PFU of HMPV or 2 × 105 and 106 PFU of RSV, respectively. The experiment was repeated three times with similar results. ***P < 0.001 (n = 5). (F) Cytokines in the BAL of HMPV- or RSV-infected mice. BALB/c mice were infected with 2 × 105 PFU of HMPV or RSV. BAL fluid was collected at different time points after infection and TNF-α, IFN-γ, IL-6, MCP-1, and IL-10 were measured by cytometric bead array. Values represent mean +/- SEM. ***P < 0.001 (n = 4).

Back to article page