Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery

Respiratory Research

Table 3 Analysis of SNPs in GSTP1 in all subjects (significant at p < 0.05) and in 4 subgroups defined by NETT based on upper lobe predominant emphysema on chest CT (upper lobe predominant vs. non-upper lobe predominant) and baseline exercise capacity (low vs. high). Subgroups with p-value <0.1 are shown

SNP	LVRS Response Phenotype	All subjects (n = 203)		Upper lobe, low exercise (n = 59)		Upper lobe, high exercise (n = 84)		Non-upper lobe, low exercise (n = 23)		Non-upper lobe, high exercise (n = 37)
		β	p	β	p	β	p	β	p	β	p
rs612020	BODE	-1.0	0.003	-1.5	0.03			-2.2	0.003
rs11227884	Post-BD FEV₁, liters	0.15	0.003
	Max work, watts	6.2	0.02	8.5	0.06

SNP = single nucleotide polymorphism; LVRS = lung volume reduction surgery; BODE = Body mass index, airflow Obstruction, Dyspnea, Exercise tolerance; BD = bronchodilator; FEV₁ = forced expiratory volume in 1 second

ISSN: 1465-993X