Effects of simulated altitude (normobaric hypoxia) on cardiorespiratory parameters and circulating endothelial precursors in healthy subjects

Table 1 Effects of hypoxia on cardiorespiratory parameters and PB-EPCs

	T0	T1	T2	ΔT0-T1%	T0 vs T1 p	T1 vs T2 p
FiO₂, %	20.9 ± 0.5	11.8 ± 0.9	21.2 ± 0.5	- 43.2 ± 5.3	< 0.0001	< 0.0001
PAO₂, mmHg	104.5 ± 14.9	30.2 ± 14.0	99.8 ± 15.8	- 71.8 ± 13.4	< 0.0001	< 0.0001
SpO₂, %	97.5 ± 1.4	86.8 ± 4.7	96.9 ± 05	- 10.9 ± 5.0	0.0005	0.0005
RF, breaths/min	16.0 ± 2.9	14.4 ± 3.4	15.8 ± 3.0	- 8.3 ± 21.6	0.235	0.118
Vt, L	0.57 ± 0.09	0.56 ± 0.26	0.6 ± 0.2	- 2.2 ± 43.6	0.937	0.426
HR, beats/min	64.0 ± 8.8	77.4 ± 10.8	66.6 ± 10.3	+ 20.9 ± 4.3	< 0.0001	0.002
SBP, mmHg	124.7 ± 4.9	120.3 ± 8.6	122.0 ± 9.0	- 3.5 ± 4.7	0.072	0.645
DBP, mmHg	71.1 ± 3.1	73.0 ± 5.6	76.3 ± 8.2	+ 2.7 ± 8.6	0.418	0.116
PB-EPCs, cells/μL	0.38 ± 0.56	0.65 ± 0.72	0.14 ± 0.20	+ 237.1 ± 264.5	0.016	0.0491

PB-EPCs, peripheral blood endothelial precursors cells; T0. baseline; T1, after 1h of standardized hypoxia; T2, 7 days after hypoxia; FiO₂, Inspiratory Fraction of Oxygen ; PAO_2, Alveolar Oxygen Partial Pressure; SpO₂, Spot Oxygen Saturation; RF, Respiratory Frequency; Vt, Tidal Volume; HR; Heart Rate; SBP, Systolic Blood Pressure; DBP, Diastolic Blood Pressure.
Values are expressed as means ± SD. A p value < 0.05 was considered significant.

ISSN: 1465-993X