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Figure 1 | Respiratory Research

Figure 1

From: Assessment of pulmonary antibodies with induced sputum and bronchoalveolar lavage induced by nasal vaccination against Pseudomonas aeruginosa: a clinical phase I/II study

Figure 1

Individual OprF-OprI-specific IgG (left column) and IgA (right columns) antibody levels in ELISA units in serum (upper panel), pooled bronchoalveolar lavage fluid (BALF, middle panel, and supernatant of induced sputum (IS, lower panel) prior to the vaccination (open circles), 4 weeks and 1 year after the booster vaccination. N = 12 volunteers received 2 applications with 1 mg of a nasal OprF-OprI gel vaccine, followed by either a third nasal vaccination (nasal booster group, closed circles, n = 6), or by a systemic vaccination with 100 μg OprF-OprI protein (systemic booster group, closed diamonds, n = 6). Mean values are indicated by the line. Mean values of the groups were compared with the paired, two-sided t-test and a p value of less than 0.05 considered significant. * assign significant differences of mean values to the pre-vaccination values, # between mean values at 4 weeks and 1 year, and §between the vaccination groups. For clarity of the figure, pre vaccination levels of both vaccination groups are shown together.

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Respiratory Research

ISSN: 1465-993X

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