Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration

Table 3 Correlational analysis of ARDS data (T0 – T2)^§

	r	p
(A)
PaO₂/FiO₂ vs. γ min	-0.831	< 0.001
PaO₂/FiO₂ vs. phospholipid-to-protein ratio	0.662	< 0.001
PaO₂/FiO₂ vs. SP-C	0.644	< 0.001
PaO₂/FiO₂ vs. SP-A	0.627	< 0.001
PaO₂/FiO₂ vs. DPPC in LA	0.590	0.003
PaO₂/FiO₂ vs. phosphatidylglycerol	0.538	< 0.001
PaO₂/FiO₂ vs. neutrophils	-0.370	0.02
PaO₂/FiO₂ vs. SP-B	0.448	0.003
PaO₂/FiO₂ vs. total BALF protein	-0.238	0.12

(B)
γ min vs. DPPC in LA	-0.754	0.012
γ min vs. SP-B	-0.708	0.002
γ min vs. total protein	0.641	0.007
γ min vs. SP-A	-0.598	0.02
γ min vs. neutrophils	0.553	0.05
γ min vs. phospholipid-to-protein ratio	-0.510	0.04
γ min vs. SP-C	0.281	0.29
γ min vs. phosphatidylglycerol	0.008	0.98

^§ Pearson correlation was performed between (A) surfactant compositional and functional parameters and PaO₂/FiO₂ and (B) between surfactant components and minimum surface tension (γ min) of the surfactant isolates for ARDS patients at T0, T1 and T2. The Pearson correlation coefficient, r, and the statistical significance, p, is given.

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