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Table 1 Clinical and basic BALF data and cell counts§

From: Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration

 

ARDS

Control

 

T0 (<24 h)

T1 (3–5 d)

T2 (7–9 d)

 

Time point of BAL

12.1 ± 1.3 hours

3.9 ± 0.6 days

8.1 ± 1.0 days

 

Number of subjects

15

15

15

15

Age [years]

52.1 ± 3.7 ***

  

30.8 ± 3.2

Sex f/m

7/8

  

9/6

Current smoker [n]

1

   

Ex smoker [n]

5

   

Never smoker [n]

9

   

Ethnic origin:

    

Caucasian

15

   

PaO 2 /FiO 2 [mm Hg]

127.8 ± 10.5 ***

129.1 ± 9.9

200.7 ± 24.1 §

511.1 ± 23.2

PEEP [cm H 2 O]

8.4 ± 0.8

8.4 ± 0.7

7.4 ± 0.7

 

Tidal Volume [ml/kg bw]

9.4 ± 0.8

9.0 ± 0.6

8.9 ± 0.6

 

PIP [cm H 2 O]

24.9 ± 1.3

25.8 ± 1.5

26.3 ± 1.9

 

APACHE II score

19.2 ± 2.2

21.5 ± 2.0

19.3 ± 1.8

 

Patients alive day 28 [n]/%

9/60%

   

Time of ventilation [d]

40.9 ± 10.8

   

Ventilator-free days at day 28 [d]

1.6 ± 1.4

   

Recovery BALF [%]

61.1 ± 3.6 ***

55.9 ± 4.6

65.1 ± 4.6

82.0 ± 2.0

Neutrophils [%]

60.8 ± 6.5 ***

47.5 ± 8.8 §

23.0 ± 7.3 §§§

0.8 ± 0.2

Lymphocytes [%]

7.2 ± 5.1

7.7 ± 4.3

7.6 ± 3.1

4.4 ± 0.8

Macrophages [%]

32.0 ± 5.2 ***

44.8 ± 8.1 §

69.4 ± 7.1 §§§

94.8 ± 0.8

Total protein [μg/ml]

1139 ± 240 ***

886 ± 167

384 ± 85 §§§

76 ± 8

  1. § All data are given as mean ± standard error. PaO2/FiO2 = mean oxygen tension in arterial blood/inspiratory oxygen fraction. PEEP = positive end-expiratory pressure. PIP = peak inspiratory pressure. APACHE II = scores on the acute physiology and chronic health evaluation. Cell counts and total proteins were measured in BALF. Tidal volume is expressed per ideal body weight. Control = healthy volunteers; ARDS = Acute respiratory distress syndrome. *** = p < 0.001: T0 compared to healthy controls (Mann-Whitney-U test) and § = p < 0.05; §§§ = p < 0.001: T1, T2 compared to T0 (Wilcoxon test).
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Respiratory Research

ISSN: 1465-993X

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