Trough FEV1 response (L)† | Trough FVC response (L)† | |||||
---|---|---|---|---|---|---|
Tiotropium | Placebo | Effect size ‡ | Tiotropium | Placebo | Effect size ‡ | |
LABA (tiotropium n = 56; placebo n = 55) | 0.05 (-0.07, 0.17) | -0.01 (-0.09, 0.07) | 0.07 (0.00, 0.14) | 0.05 (-0.12, 0.32) | -0.05 (-0.21, 0.08) | 0.12 (0.02, 0.23) |
ICS (tiotropium n = 126, placebo n = 113) | 0.12 (-0.05, 0.26) | 0.00 (-0.09, 0.11) | 0.09 (0.04, 0.15) | 0.09 (-0.08, 0.35) | -0.01 (-0.17, 0.14) | 0.14 (0.06, 0.22) |
ICS; no LABA (tiotropium n = 76, placebo n = 65) | 0.14 (-0.02, 0.33) | 0.02 (-0.08, 0.14) | 0.09 (0.01, 0.18) | 0.11 (-0.08, 0.43) | 0.02 (-0.18, 0.17) | 0.14 (0.03, 0.26) |
LABA plus ICS (tiotropium n = 50, placebo n = 48) | 0.06 (-0.07, 0.19) | -0.02 (-0.09, 0.07) | 0.09 (0.01, 0.17) | 0.05 (-0.09, 0.34) | -0.04 (-0.18, 0.08) | 0.13 (0.02, 0.26) |
No LABA; no ICS (tiotropium n = 59, placebo n = 63) | 0.09 (-0.02, 0.31) | 0.09 (-0.01, 0.27) | 0.01 (-0.07, 0.09) | 0.13 (-0.06, 0.30) | 0.06 (-0.14, 0.21) | 0.08 (-0.02, 0.19) |