Table 3 Effects of chemotherapeutical treatment on expression of proliferation (Ki-67, BrdU) and of apoptosis (cleaved caspase-3) in human NSCLC tissue specimens. Data are expressed as mean values of percentages ± SEM of positively stained tumour cells.
From: A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapy
Ki-67 | Treatment | Two-tailed P-Value | Number of Tested Samples | ||
|---|---|---|---|---|---|
AC | RPMI | ||||
CARB | 9.8 ± 2.2 | 18.0 ± 2.6 | 0.032 | N = 19 | |
VIN | 10.9 ± 2.4 | 18.2 ± 2.4 | 0.047 | N = 21 | |
GEM | 11.4 ± 2.1 | 21.2 ± 2.1 | 0.0049 | N = 17 | |
SCC | |||||
CARB | 19.1 ± 2.4 | 26.6 ± 2.4 | 0.065 | N = 19 | |
VIN | 18.1 ± 2.6 | 27.3 ± 2.4 | 0.0026 | N = 20 | |
GEM | 21.2 ± 2.9 | 28.8 ± 2.5 | 0.07 | N = 17 | |
BrdU | |||||
AC | RPMI | ||||
CARB | 0.9 ± 0.5 | 5.5 ± 1.7 | 0.006 | N = 19 | |
VIN | 0.2 ± 0.1 | 6.0 ± 1.9 | 0.002 | N = 15 | |
GEM | 1.0 ± 0.4 | 6.8 ± 2.3 | 0.063 | N = 12 | |
SCC | |||||
CARB | 1.4 ± 0.6 | 4.7 ± 1.4 | 0.084 | N = 9 | |
VIN | 0.8 ± 0.4 | 4.9 ± 1.7 | 0.079 | N = 7 | |
GEM | 1.3 ± 0.7 | 4.9 ± 1.7 | 0.063 | N = 7 | |
Caspase-3 | |||||
AC | RPMI | ||||
CARB | 19.0 ± 4.6 | 11.1 ± 2.5 | 0.47 | N = 19 | |
VIN | 22.0 ± 5.5 | 10.6 ± 2.4 | 0.163 | N = 20 | |
GEM | 20.8 ± 6.4 | 10.1 ± 2.9 | 0.559 | N = 16 | |
SCC | |||||
CARB | 13.7 ± 3.2 | 8.3 ± 1.2 | 0.483 | N = 19 | |
VIN | 15.1 ± 3.1 | 7.8 ± 1.1 | 0.24 | N = 18 | |
GEM | 17.5 ± 3.1 | 8.3 ± 1.4 | 0.029 | N = 15 |