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Table 3 Outcomes for survivors

From: Azithromycin in the extremely low birth weight infant for the prevention of Bronchopulmonary Dysplasia: a pilot study

 

Azithromycin Group

(n = 14)

Placebo Group

(n = 12)

p-value

Incidence of BPD-no. (%)

9 (64.3)

10 (83.3)

0.26

Duration of Mechanical Ventilation-median (range)

13 (1–47)

35 (1–112)

0.02

Postnatal-steroid

3 (18.8)

8 (66.7)

0.02

Days of CPAP (range)

8 ± 7

8 ± 6

0.98

Grade III or IV IVH-no. (%)

2 (14)

2 (16)

0.86

PVL on HUS-no. (%)

1 (7)

2 (16)

0.58

Abnormal Transaminases (AST)

0

1 (8)

0.46

Bilirubin Peak

6.9 ± 1.8

6.4 ± 2.1

0.54

Days to full feeds‡

17 ± 5

18 ± 4

0.76

Feeding intolerance*-no. (%)

4 (29)

7 (58)

0.12

Necrotizing Enterocolitis-no. (%)

0

1 (8)

0.46

Abnormal hearing screen-no. (%)

0

3 (25)

0.08

Bacterial Infection:

   

Blood-no. (%)

8 (57)

5 (42)

0.43

Urine-no. (%)

0

3 (25)

0.08

CSF-no. (%)

0

2 (17)

0.20

Fungal Infection:

   

Blood-no. (%)

2 (14)

1 (8)

1.0

Urine-no. (%)

0

1 (8)

0.46

CSF-no. (%)

1 (7)

0

1.0

Days of Antibiotics§

12 ± 11

24 ± 23

0.09

Caffeine Therapy-no. (%)

13 (92)

10 (83)

0.58

PDA†-no. (%)

7 (50)

9 (75.0)

0.18

Indomethacin¥

   

Median

1

1

0.48

Interquartile range

0–1

0–2

 

PDA ligated-no. (%)

3 (21)

3 (25)

0.82

Diuretics-no. (%)

5 (35)

7 (58)

0.24

Days of Diuretics

12 ± 25

28 ± 42

0.23

Bronchodilators-no. (%)

4 (28)

8 (67)

0.05

Days of Bronchodilators

7 ± 15

24 ± 25

0.04

Hospital days

77 ± 15

101 ± 32

0.02

  1. All data analysis was performed using ANOVA (mean ± sd), except for apgar scores and days of mechanical ventilation, which analyzed using median test. *Defined as feeds being held for more than 24 hours, while on study. †Confirmed by echocardiogram. ‡Defined as when TPN was discontinued. §Excluding azithromycin. ¥Performed using wilcoxon rank sum test.