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Table 2 Outcomes for all patients

From: Azithromycin in the extremely low birth weight infant for the prevention of Bronchopulmonary Dysplasia: a pilot study

 

Azithromycin Group

(n = 19)

Placebo Group

(n = 16)

p-value

Mortality-no. (%)

5 (26.3)

4 (25)

0.9

Incidence of BPD-no. (%)

9 (64.3)

10 (83.3)

0.26

Duration of Mechanical Ventilation-median (range)

10 (1–145)

16 (1–112)

0.40

Postnatal-steroid

6 (31.5)

10 (62.5)

0.05

Days of CPAP (range)

6 ± 7

6 ± 6

0.84

Grade III or IV IVH-no. (%)

5 (26)

5 (33)

0.65

PVL on HUS-no. (%)

1 (5)

3 (19)

0.20

Abnormal Transaminases (AST)

0

1

0.20

Bilirubin Peak

6.5 ± 2

6.3 ± 1.9

0.68

Days to full feeds‡

18 ± 5

18 ± 54

0.95

Feeding intolerance*-no. (%)

5 (26)

9 (56)

0.07

Necrotizing Enterocolitis-no. (%)

0

1 (6)

0.20

Abnormal hearing screen-no. (%)

0

3 (25)

0.08

Bacterial Infection:

   

Blood-no. (%)

10 (52)

6 (38)

0.35

Urine-no. (%)

1 (5)

4 (25)

0.15

CSF-no. (%)

0

2 (12)

0.20

Fungal Infection:

   

Blood-no. (%)

3 (16)

2 (12)

0.78

Urine-no. (%)

0

2 (12)

0.20

CSF-no. (%)

1 (5)

0

1

Days of Antibiotics§

10 ± 10

19 ± 21

0.10

Caffeine Therapy-no. (%)

13 (68)

10 (62)

0.71

PDA†-no. (%)

10 (52)

12 (75)

0.16

Courses of indomethacin

  

0.49

Median

1

1

 

Interquartile range

0–1

0–2

 

PDA ligated-no. (%)

3 (15)

4 (25)

0.49

Diuretics-no. (%)

6 (31)

8 (50)

0.26

Days of Diuretics

14 ± 30

21 ± 38

0.53

Bronchodilators-no. (%)

5 (26)

8 (50)

0.14

Days of Bronchodilators

10 ± 25

18 ± 24

0.34

Hospital days

67 ± 40

78 ± 50

0.47

  1. All data analysis was performed using ANOVA (mean ± sd), except for indomethacin and days of mechanical ventilation, which was analyzed using median test. *Defined as feeds being held for more than 24 hours, while on study. †Confirmed by echocardiogram. ‡Defined as when TPN was discontinued. §Excluding azithromycin.