Table 3 Stereological data on alveolar type II cells and intracellular surfactant
Healthy animals | Lavaged animals | |||
|---|---|---|---|---|
Parameter | Gas | PF5080 | Gas | PF5080 |
N(typeII/lung) [106] | 229.3 ± 85.1 | 220.3 ± 72.5 | 209.1 ± 49.8 | 285.7 ± 62.6 |
| 385.7 ± 27.2 | 391.5 ± 27.5 | 344.7 ± 43.9 | 337.8 ± 16.3* |
V(lb/typeII) [μm3] | 61.3 ± 14.1 | 49.9 ± 5.5 | 26.9 ± 7.1* | 27.9 ± 1.7* |
V(lb/lung) [mm3] | 14.0 ± 6.3 | 11.0 ± 4.0 | 5.5 ± 1.5* | 8.0 ± 2.0 |
V V (lb/mm3par) [106 μm3] | 2.9 ± 0.9 | 2.7 ± 0.4 | 1.6 ± 0.3* | 1.6 ± 0.3* |
(typeII) [μm3]- Abbreviations: N(typeII/lung) = number of type II cells per lung;
(typeII) = number-weighted mean volume of type II cells; V(lb/typeII) = total volume of lamellar bodies per type II cell; V(lb/lung) = total volume of lamellar bodies per lung; V
V
(lb/mm3par) = volume density of lamellar bodies per mm3 parenchyma. Data are presented as mean ± SD. * p < 0.05 Lavaged vs. Healthy.