Table 2 Stereological data on parenchymal architecture
Healthy animals | Lavaged animals | |||
|---|---|---|---|---|
Parameter | Gas | PF5080 | Gas | PF5080 |
V(lung) [cm3] | 5.00 ± 0.8 | 4.42 ± 1.7 | 3.76 ± 0.3* | 5.34 ± 1.1† |
V V (par/lung) | 0.94 ± 0.02 | 0.95 ± 0.03 | 0.92 ± 0.04 | 0.95 ± 0.02 |
V(sep) [cm3] | 1.4 ± 0.2 | 1.1 ± 0.3 | 1.0 ± 0.2* | 1.3 ± 0.2 |
| 5.7 ± 1.3 | 6.0 ± 1.0 | 4.1 ± 1.0 | 4.1 ± 0.4* |
S(alvepi) [m2] | 0.25 ± 0.1 | 0.19 ± 0.1 | 0.24 ± 0.04 | 0.33 ± 0.1* |
| 98.7 ± 1.6 | 95.3 ± 3.7 | 88.8 ± 15.7 | 81.6 ± 20.6 |
(sep) [μm]
(air) [103 μm]- Abbreviations: V(lung) = total lung volume; V
V
(par/lung) = volume fraction of parenchyma; V(sep) = total volume of alveolar septal tissue;
(sep) = mean alveolar septal thickness; S(alvepi) = alveolar epithelial surface area; 
(air) = volume-weighted mean volume of distal air spaces. - Data are presented as mean ± SD. * p < 0.05 Lavaged vs. Healthy. † p < 0.05 PF5080 vs. Gas.