Figure 3
From: Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs
Effect of inhaled iloprost on U46619-elevated pulmonary artery pressure in untreated and desensitized (post iloprost infusion) lungs. Inhalation of aerosolized iloprost for 10 min (deposited dose 75 ng) resulted in a significant reduction of the U46619-induced pulmonary hypertension, with PAP values decreasing by a mean of 6.3 mmHg. The vasodilatory potency of inhaled iloprost was completely lost in the desensitization group (iloprost infusion for 240 min). *: p < 0.05 as compared to U46619-elevated pulmonary artery pressure.