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Figure 4 | Respiratory Research

Figure 4

From: Anti-inflammatory properties of desipramine and fluoxetine

Figure 4

Desipramine and fluoxetine inhibit release of TNF-Ī± from cultured monocytes. A, Purified human monocytes were seeded at 100 000 cells per well and were left untreated (UT) or stimulated for 20 h with 100 ng/ml of LPS. Concentration of TNF-Ī± in supernatants was then measured. *p < 0.0001 versus untreated, by Welch t test. B, Cells were treated for 20 h with 100 ng/ml of LPS in the presence of increasing concentrations of desipramine (DMI) or fluoxetine (Fluo). Data are shown as the percentage of LPS-induced TNF-Ī± release. *p < 0.05 and **p < 0.001 versus LPS alone, by ANOVA with Bonferroni post-test.

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