Figure 3

Effect of a curative treatment with desipramine or fluoxetine on LPS-induced mortality. Mice (n = 10–21 per group) were treated with prednisolone (Pred, 20 mg/kg, i.p), desipramine (DMI, 20 mg/kg, i.p.), fluoxetine (Fluo, 20 mg/kg, i.p.) or saline 4, 8, 12, 24, and 30 h after administration of LPS (50 mg/kg, i.p.) as indicated. Kaplan-Meier survival curves represent the percentage of surviving individuals in each groups. Mortality was evaluated daily (no additional death occurred after 96 h). *p = 0.0274 versus saline, by Fisher's exact test.