Figure 2

Pretreatment with desipramine and fluoxetine prevents LPS-induced mortality. Mice (n = 10–31 per group) were injected with saline, desipramine (DMI, 20 mg/kg, i.p.), fluoxetine (Fluo, 20 mg/kg, i.p.) or prednisolone (Pred, 20 mg/kg, i.p.) as indicated 30 min before administration of LPS (50 mg/kg, i.p.). Kaplan-Meier survival curves represent the percentage of surviving individuals in each groups. Survival is shown over a 96 h period (no additional death occurred after 96 h). *p = 0.0129 and **p = 0.0005 versus saline, by Fisher's exact test.