Table 3 Cellular localization and functions of genes regulated by V2O5 grouped by functional categories (See Fig. 3).
Accession#a | Gene Symbol | Gene Name | Localization | Function |
|---|---|---|---|---|
Cytokines and Chemokines | ||||
Hs.512234 | IL6 | lnterleukin-6 (interferon beta2) | Secreted | Inflammation |
Hs.624 | IL8 | lnterleukin-8 | Secreted | Neutrophil Chemotaxis |
Hs. 168132 | IL15 | lnterleukin-15 | Secreted | T Lymphocyte Proliferation |
Hs.271387 | CCL8 | CC Chemokine Ligand 8 | Secreted | Neutrophil Chemotaxis |
Hs.77367 | CXCL9 | Chemokine (C-X-C motif) Ligand 9 (Mig) | Secreted | Inflammation |
Hs.632586 | CXCL10 | Chemokine (C-X-C motif) Ligand 10 (IP-10) | Secreted | Inflammation |
Growth Factors | ||||
Hs.73793 | VEGF | Vascular Endothelial Cell Growth Factor | Secreted | Endothelial Cell Growth |
Hs.396530 | HGF | Hepatocyte Growth Factor | Secreted | Epithelial Cell Growth |
Hs.799 | HBEGF | Heparin-Binding EGF-like Growth Factor | Membrane/Secreted | Fibroblast Growth |
Hs.591346 | CTGF | Connective Tissue Growth Factor | Secreted | Collagen Synthesis |
Hs.111 | FGF9 | Fibroblast Growth Factor-9 | Membrane/Secreted | Fibroblast Growth |
Hs.284244 | FGF2 | Fibroblast Growth Factor-2 | Membrane/Secreted | Fibroblast Growth |
STAT Signaling | ||||
Hs.591081 | JAK2 | Janus Activated Kinase-2 | Membrane | STAT Phosphorylation |
Hs.436061 | IRF1 | Interferon-Regulatory Factor-1 | Cytoplasmic/Nuclear | Transcriptional Regulation |
Hs.527973 | SOCS3 | Suppressor of Cytokine Signaling-3 | Cytoplasmic | Cell Signaling |
Hs.50640 | SOCS1 | Suppressor of Cytokine Signaling-1 | Cytoplasmic | Cell Signaling |
Hs.470943 | STAT1 | Signal Transducer Activator of Transcription | Cytoplasmic | Growth Arrest and Apoptosis |
Hs.520414 | IFNGR1 | Interferon Gamma Receptor- 1 | Membrane | Cell Signaling |
Cell Cycle Regulation | ||||
Hs.238990 | CDKN1B | Cyclin-Dependent Kinase lnhbitior-1B (Kip1) | Nuclear | Cell Cycle Arrest |
Hs. 106070 | CDKN1C | Cyclin-Dependent Kinase lnhibitor-1C (Kip2) | Nuclear | Cell Cycle Arrest |
Hs.525324 | CDKN2C | Cyclin-Dependent Kinase lnhibitor-2C | Nuclear | Cell Cycle Arrest |
Hs.557646 | CDK9 | Cyclin-Dependent Kinase-9 | Nuclear | Transcriptional Regulation |
Hs. 184298 | CDK7 | Cyclin-Dependent Kinase-7 | Nuclear | Transcriptional Regulation |
Hs. 13291 | CCNG2 | Cyclin G2 | Nuclear | Cell Cycle Arrest |
Oxidative Stress | ||||
Hs.475970 | OXSR1 | Oxidative Stress Response 1 | Cytoplasmic | Intracellular Kinase |
Hs.487046 | SOD2 | Superoxide Dismutase 2 (SOD2) | Cytoplasmic | Peroxide Generation |
Hs. 148778 | OXR1 | Oxidative Resistance 1 | Cytoplasmic | Anti-Oxidant |
Hs.462585 | PIPOX | Pipecolic Acid Oxidase | Cytoplasmic | Peroxide Generation |
Hs.465870 | KEAP1 | Kelch-like ECH-associated protein 1 | Cytoplasmic | Redox Homeostasis |
Hs.406515 | NQO1 | NAD(P)H:quinone oxidoreductase 1 | Cytoplasmic | Redox Homeostasis |
TGF-beta Signaling and Collagen | ||||
Hs. 133379 | TGFB2 | Transforming Growth Factor beta-2 | Secreted | Matrix Synthesis, Immunity |
Hs.519005 | SMAD1 | mothers against DPP homolog 1 | Cytoplasmic | Cell Signaling |
Hs. 189329 | SMURF1 | Smad Ubiquitin Regulatory Factor-1 | Cytoplasmic | Cell Signaling |
Hs.489142 | COL1A2 | Collagen 1A2 | Secreted | Structural Protein |
Hs. 172928 | COL1A1 | Collagen 1A1 | Secreted | Structural Protein |
Hs.443625 | COL3A1 | Collagen 3A1 | Secreted | Structural Protein |