Table 2 Functional analysis of genes induced or suppressed by V₂O₅ in human lung fibroblasts.^a

Induced Genes

response to external stimulus

32

8.47

1.43E-05

chemotaxis

13

3.44

6.96E-05

response to wounding

25

6.61

1.81E-04

response to chemical stimulus

23

6.08

2.51 E-04

response to stress

44

11.64

0.003553

cell motility

15

3.97

0.005005

RNA processing

19

5.03

0.005027

RNA splicing

11

2.91

0.007903

inflammatory response

13

3.44

0.011869

positive regulation of cell proliferation

10

2.65

0.013783

immune response

33

8.73

0.018616

cell-cell signaling

23

6.08

0.042107

Suppressed Genes

regulation of transcription

298

19.34

3.61 E-25

ubiquitin cycle

81

5.26

1.16E-10

RNA processing

72

4.67

6.25E-10

cell cycle

113

7.33

4.42E-08

response to DNA damage stimulus

52

3.37

1.13E-07

DNA metabolism

94

6.10

2.23E-06

DNA repair

43

2.79

1.23E-05

RNA splicing

33

2.14

2.56E-05

protein kinase cascade

50

3.24

3.39E-05

cell division

31

2.01

2.71 E-04

nuclear transport

23

1.49

6.27E-04

phosphorylation

88

5.71

8.76E-04

protein metabolism

311

20.18

0.001149

steroid hormone receptor signaling pathway

13

0.84

0.001328

RNA transport

12

0.78

0.002917

programmed cell death

76

4.93

0.003907

regulation of cell growth

22

1.43

0.004779

chromatin modification

22

1.43

0.005351

JAK-STAT cascade

9

0.58

0.008321

cell cycle arrest

14

0.91

0.013090

Wnt receptor signaling pathway

18

1.17

0.020398

protein transport

65

4.22

0.034144

insulin receptor signaling pathway

6

0.39

0.039295

l-kappaB kinase/NF-kappaB cascade

18

1.17

0.042224