Table 1 Temporal expression categories of selected genes significantly induced or suppressed by V2O5 exposure and their cellular localization and functions (See Fig. 2).
Accession#a | Gene Symbol | Gene Name | Localization | Function |
|---|---|---|---|---|
Progressively Induced Genes | ||||
Hs.25590 | STC1 | Stanniocalcin | Secreted | Cellular Metabolism |
Hs.448611 | PBEF1 | Pre-B Cell Colony Enhancing Factor 1 | Secreted | Inflammation |
Hs.78913 | CX3CR1 | Chemokine (C-X3-C motif) Receptor 1 | Membrane | Inflammation |
Hs.515258 | GDF15 | Growth and Differentiation Factor-15 | Secreted | Growth Inhibition |
Hs.471221 | KLF7 | Kruppel-like factor 7 | Nuclear | Transcriptional Regulation |
Hs.525704 | JUN | V-jun sarcoma virus 17 oncogene | Nuclear | Transcriptional Regulation |
Progressively Suppressed Gene | ||||
Hs.65029 | GAS1 | Growth Arrest Specific Gene 1 | Nuclear | Growth Arrest and Apoptosis |
Hs.519162 | BTG2 | B-Cell Translocation Gene 2 | Nuclear | Growth Arrest |
Hs.255935 | BTG1 | B-Cell Translocation Gene 1 | Nuclear | Growth Arrest |
Hs.8375 | TRAF4 | TNF Receptor-Associated Factor | Membrane | Inflammation/Immunity |
Hs. 109225 | VCAM1 | Vascular Cell Adhesion Molecule 1 | Membrane | Cell Adhesion |
Hs.519909 | MARCKS | Myristolated Alanine-rich C Kinase Substrate | Cytoplasmic | Cell Signaling |
Early Induced I/Late Suppressed Genes | ||||
Hs.298654 | DUSP6 | MAP kinase phosphatase 3 | Cytoplasmic | Cell Signaling |
Hs.532411 | LYST | Lysosomal Trafficking Regulator Gene | Cytoplasmic | Cell Signaling |
Hs.514746 | GATA6 | GATA6 Transcription Factor | Nuclear | Transcriptional Regulation |
Hs.37982 | NEDD9 | Neural expressed Develop. down-regulated 9 | Membrane | Cell Adhesion |
Hs.502328 | CD44 | CD44 molecule (Indian blood group) | Membrane | Cell Signaling |
Hs.59332 | SPRED2 | Sprouty-Related EVH Domain-2 | Cytoplasmic | Cell Signaling |
Biphasic Induced Genes | ||||
Hs.326035 | EGR1 | Early Growth Response-1 Gene | Cytoplasmic/Nuclear | Transcriptional Regulation |
Hs.534313 | EGR3 | Early Growth Response-3 Gene | Cytoplasmic/Nuclear | Transcriptional Regulation |
Hs.73853 | BMP2 | Bone Morphogenic Protein-1 | Secreted | Cell Differentiation |
Hs.591241 | CCNT2 | Cyclin T2 | Nuclear | Cell Cycle Regulation |
Hs.62661 | GBP1 | guanylate-binding protein 1, IFN-inducible | Cytoplasmic | Antiviral Activitiy |
Hs.419240 | SLC2A3 | Solute Carrier Family 2 (GLUT3) | Membrane | Metabolism |