Figure 2
From: Resolution of LPS-induced airway inflammation and goblet cell hyperplasia is independent of IL-18
Inflammatory mediators detected in the BALF. A The amount of LPS recovered in the bronchoalveolar lavages was measured using the Limulus Amoebocyte Assay and expressed in international endotoxin units (EU/ml). BALF from rats instilled with saline or 1000 μg LPS were analyzed for cytokines and growth factors by multiplex ELISA and levels of IL-1α, IL-1β, IL-6, TNF-α, GRO-KC and MCP-1 over 90 d post instillation are show. B. VEGF was only increased at 8 d post- instillation of 1000 μg LPS compared to saline-instilled rats. C. IL-18 and IL-9 exhibit a cyclic pattern of expression over 90 d post instillation. Bars represent group mean values ± SEM (n = 5 rats per experimental group) * = statistically different from saline-instilled controls (P < 0.05).