Table 1 Profiling of TM30089 at relevant 7TM receptors (binding or functional assays) and enzymes (enzymatic assays).
Receptor | Assay typea | % of controlb |
|---|---|---|
AT1 | B | 90.1 ± 2.8 |
AT2 | B | 98.1 ± 1.4 |
BLT1 | B | 89.3 ± 3.5 |
C3a | F | 88.7 ± 5.9 |
C5a | B | 108.7 ± 6.3 |
ChemR23 | F | 96.6 ± 1.6 |
CXCR2 | B | 104.6 ± 6.1 |
CysLT1 | B | 116.9 ± 10.5 |
Glucocorticoid | B | 98.9 ± 11.3 |
Muscarinic (non-selective) | B | 106.7 ± 8.5 |
Muscarinic (M2-selective) | B | 97.5 ± 1.9 |
Phospholipase A2 | E | 101.5 ± 1.0 |
COX1 | E | 109.6 ± 3.6 |
COX2 | E | 123.8 ± 13.4 |
iNOS | E | 102.3 ± 3.6 |