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Figure 4 | Respiratory Research

Figure 4

From: Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells

Figure 4

AP-1 repressor blocked S. pneumoniae-induced IL-8 release. HEK293 cells were transfected with plasmids encoding TLR2, as well as empty vector (CMV500), AP-1 repressor (CMV500-A-Fos), Fra1 antisense (AS Fra1), or Fra2 antisense (AS Fra2), respectively. Then, cells were infected with S. pneumoniae strain R6x (105 cfu/ml) or stimulated with TNFα (50 ng/ml) for 15 h, and IL-8 concentration was measured in the supernatant. *, p < 0.01 vs. control; #, p < 0.01 vs. infected cells with empty vector at least in three independent experiments.

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