Figure 3
From: Migratory marker expression in fibroblast foci of idiopathic pulmonary fibrosis
Characterisation of "sandwich-FF" by double-marker immunostaining in UIP biopsies. In (a) nuclear immunoreactivity of ΔN-p63 (brown-black), a well established marker of bronchiolar basal cells, clearly defines the nature of the cells expressing LAM5γ2 (cytoplasmic red immunoreactivity). In (b), another sandwich lesion immunostained by the double marker technique and showing strong expression of tenascin in the cluster of myofibroblasts is seen (red). The cluster of basal cells located between tenascin+ myofibroblasts and negative luminal bronchiolar cells strongly expresses LAM5γ2 (arrow).