TY - JOUR AU - Chilosi, Marco AU - Zamò, Alberto AU - Doglioni, Claudio AU - Reghellin, Daniela AU - Lestani, Maurizio AU - Montagna, Licia AU - Pedron, Serena AU - Ennas, Maria Grazia AU - Cancellieri, Alessandra AU - Murer, Bruno AU - Poletti, Venerino PY - 2006 DA - 2006/06/30 TI - Migratory marker expression in fibroblast foci of idiopathic pulmonary fibrosis JO - Respiratory Research SP - 95 VL - 7 IS - 1 AB - Fibroblast foci (FF) are considered a relevant morphologic marker of idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP), and are recognised as sites where fibrotic responses are initiated and/or perpetuated in this severe disease. Despite their relevance, the cellular and molecular mechanisms responsible for the formation of FF and their role in tissue remodelling are poorly defined. In previous studies we have provided evidence of abnormal activation of the wnt-signaling-pathway in IPF/UIP that is centred on FF and the overlying epithelium. This important morphogenetic pathway is able to trigger epithelial-mesenchymal-transition (EMT), a mechanism involved in developmental and metastatic processes, which is also potentially involved in pulmonary fibrosis. SN - 1465-993X UR - https://doi.org/10.1186/1465-9921-7-95 DO - 10.1186/1465-9921-7-95 ID - Chilosi2006 ER -