The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations

Table 6 Comparison of previously reported association results¹ with ADAM33 polymorphisms

Study	Study population	N²	*ADAM33* SNPs and reported associations
	cc = case control fa = family study	cases/controls families (ind.)	F+1	I1	L-1	M+1	Q-1	S1	S2	ST+1	ST+4	ST+5	ST+7	T1	T2	T+1	V-1	V1	V4
Van Eerdewegh et al.	US/UK combined (cc)	130/217	neg	neg	neg	neg	A	A	neg	neg	A	neg	A	neg	neg	neg	A	neg	A
	UK (cc)	(not reported)	A	neg	neg	neg	A	A	A	neg	A	neg	neg	neg	neg	neg	A	neg	A
	US (cc)	(not reported)	neg	A	A	A	neg	neg	neg	neg	neg	neg	neg	A	A	A	neg	neg	neg
	US/UK (fa)	460fa (1840)						A						B			neg	neg	neg
Lind et al.	Mexican (cc)	190/160						neg						neg	neg		neg	neg	neg
	Puerto Rican (cc)	183/165						neg						neg	neg		neg	neg	neg
	Mexican/P. Rican (fa)	583fa (1749)³						neg						neg	neg		neg	neg	neg
Raby et al. ⁴	Non-Hispanic white (fa)	474 (1462)				neg			neg		neg	neg		neg	neg	neg	neg		neg
	Hispanic (fa)	47 (149)				neg			neg		neg	neg		A	neg	A	neg		neg
	African American (fa)	66 (203)				neg			neg		neg	neg		neg	neg	neg	neg		neg
Werner et al.	German (cc)	48/499	neg	neg		neg	neg	neg	neg	neg	neg	B	A	neg	neg	neg	neg		neg
	German (fa)	171fa (732)	A, B, AB	neg		neg	neg	neg	B, AB	neg	A	A	neg	neg	neg	neg	neg		neg
Howard et. al.	African American (cc)	161/265⁵						neg	A		AT		neg	neg	neg		neg		AT
	US White (cc)	220/229⁵						neg	A⁶, AT		neg		A	A, AT	A, AT		neg		neg
	US Hispanic (cc)	113/127⁵						neg	A		AT		neg	A⁶, AT	A, AT		AT		neg
	Dutch White (cc)	180/133⁵						AT	AT		neg		A, AT	neg	neg		AT		A
Blakey et al.	Icelandic (cc)	348/262	neg			neg	neg	neg	neg		neg	neg	neg	neg	neg	neg	neg		neg
	Nottingham (fa)	60fa (240)	neg			neg	neg	neg			neg	neg	neg	neg	neg	neg	neg	neg	neg

¹ association with asthma (= A), BHR (= B), Asthma and BHR (= AB) or Atopy (= AT) in different studies; SNPs which are not significantly associated = neg
² in case-control studies number of cases and controls, in family studies number of families and individuals
³265 Mexican families and 318 Puerto Rican families, no association neither in single nor in pooled population
⁴in the study of Raby et al. 8 additional SNPs were investigated: G1, I1, KL+3, N1, S+1, T+2, V-2, V3. None of the additional SNPs showed an association with asthma.
⁵N is reported as maximum number of successfully genotyped subjects
⁶only a trend (0.05 < p ≤ 0.06)

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