The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations

Schedel, Michaela; Depner, Martin; Schoen, Carola; Weiland, Stephan K; Vogelberg, Christian; Niggemann, Bodo; Lau, Susanne; Illig, Thomas; Klopp, Norman; Wahn, Ulrich; von Mutius, Erika; Nickel, Renate; Kabesch, Michael

doi:10.1186/1465-9921-7-91

Table 3b Lung function parameters in the case-control study for all controls *)

From: The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations

SNP		N¹⁾	MEF₂₅ (%) Mean ± SD	MEF₅₀ (%) Mean ± SD	MEF₇₅ (%) Mean ± SD	FEV1 (%) Mean ± SD	FVC (%) Mean ± SD
*F+1*	wild type	291	98.48 ± 25.83	97.93 ± 19.80	99.22 ± 17.82	100.59 ± 9.86	98.28 ± 10.49
	heterozygous	348	101.46 ± 30.46	99.08 ± 21.41	100.69 ± 17.83	101.76 ± 10.29	99.08 ± 10.26
	homozygous	111	99.44 ± 29.96	99.63 ± 20.23	101.52 ± 19.80	101.38 ± 10.75	98.47 ± 10.38
*M+1*	wild type	522	99.25 ± 27.06	98.22 ± 20.12	99.46 ± 17.92*^d	101.06 ± 10.11	98.46 ± 10.51
	heterozygous	201	101.97 ± 32.25	100.01 ± 21.94	102.51 ± 18.60	102.10 ± 10.69	99.39 ± 10.29
	homozygous	12	95.45 ± 35.80	104.74 ± 19.55	104.98 ± 13.31	98.63 ± 8.56	96.65 ± 8.30
S1	wild type	627	100.12 ± 29.00	99.05 ± 20.58	100.58 ± 17.89	101.18 ± 10.28	98.67 ± 10.52
	heterozygous	116	98.23 ± 27.90	97.01 ± 21.40	99.16 ± 19.84	101.78 ± 10.41	99.29 ± 10.11
	homozygous	6	95.19 ± 21.20	98.62 ± 16.03	103.61 ± 13.45	103.74 ± 10.25	100.29 ± 11.22
S2	wild type	381	99.51 ± 26.91	98.44 ± 20.04	98.82 ± 17.78*^d	100.94 ± 10.08	98.34 ± 10.67
	heterozygous	292	101.59 ± 31.92	99.11 ± 22.33	101.88 ± 18.68	102.09 ± 10.56	99.55 ± 10.28
	homozygous	62	97.76 ± 25.55	100.37 ± 16.24	101.35 ± 16.99	102.51 ± 9.76	98.97 ± 9.91
*ST+4*	wild type	257	100.02 ± 28.64	98.04 ± 20.98	100.06 ± 17.63	101.58 ± 9.86	99.20 ± 9.75
	heterozygous	365	100.09 ± 28.74	99.28 ± 21.10	101.17 ± 19.05	101.39 ± 10.50	98.55 ± 10.50
	homozygous	114	98.52 ± 28.40	98.83 ± 18.79	98.41 ± 16.62	100.07 ± 10.09	98.18 ± 11.43
*ST+5*	wild type	222	100.79 ± 31.48	101.33 ± 20.02*^d	101.79 ± 17.87	101.33 ± 10.00	98.98 ± 10.29
	heterozygous	380	99.54 ± 28.10	97.52 ± 21.27	99.77 ± 18.20	100.85 ± 10.58	98.12 ± 10.82
	homozygous	148	99.48 ± 25.81	97.72 ± 19.54	99.23 ± 18.08	102.19 ± 9.46	99.74 ± 9.19
*ST+7*	wild type	507	100.34 ± 28.71	99.01 ± 20.67	100.26 ± 17.65	101.40 ± 10.17	98.93 ± 10.29
	heterozygous	213	98.76 ± 29.25	98.00 ± 20.58	100.11 ± 19.04	100.65 ± 9.99	98.01 ± 10.35
	homozygous	32	101.56 ± 24.74	98.45 ± 20.33	99.70 ± 19.21	103.37 ± 12.14	100.57 ± 12.16
T1	wild type	531	99.34 ± 27.07	98.23 ± 20.15	99.49 ± 18.08	101.07 ± 10.13	98.58 ± 10.53
	heterozygous	205	101.94 ± 32.34	99.58 ± 21.96	101.97 ± 18.39	101.81 ± 10.47	99.12 ± 10.14
	homozygous	15	95.29 ± 31.85	103.19 ± 18.07	101.58 ± 14.14	101.17 ± 9.28	98.59 ± 8.47
T2	wild type	532	99.31 ± 27.05	98.23 ± 20.13	99.51 ± 18.07	101.07 ± 10.12	98.57 ± 10.52
	heterozygous	204	102.01 ± 32.41	99.58 ± 22.01	101.92 ± 18.42	101.80 ± 10.49	99.09 ± 10.16
	homozygous	15	95.29 ± 31.85	103.19 ± 18.07	101.58 ± 14.14	101.17 ± 9.28	98.59 ± 8.47
V4	wild type	474	100.07 ± 28.66	98.91 ± 21.18	100.74 ± 18.35	101.32 ± 10.45	98.76 ± 10.49
	heterozygous	249	99.87 ± 29.37	98.91 ± 19.75	99.86 ± 17.75	101.62 ± 9.80	99.16 ± 10.07
	homozygous	35	99.31 ± 25.64	96.87 ± 19.30	100.16 ± 19.15	100.29 ± 11.81	96.95 ± 12.34

*) significant differences in lung function parameters between genotypes are printed in bold letters,
*^v denotes significant differences in variance analysis,
*^d denotes significant differences in t-test for a dominant model,
*^r significant differences in t-test for a recessive model
¹⁾N refers to the first lung function parameter. Minimal deviations of N in the other lung function parameters are possible.

Back to article page

ISSN: 1465-993X

Contact us

General enquiries: journalsubmissions@springernature.com

Respiratory Research

Contact us