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Table 3a Lung function parameters in the case-control study for all cases *)

From: The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations

SNP

 

N1)

MEF25 (%) Mean ± SD

MEF50 (%) Mean ± SD

MEF75 (%) Mean ± SD

FEV1 (%) Mean ± SD

FVC (%) Mean ± SD

F+1

wild type

165

89.82 ± 29.66

89.47 ± 22.54

91.90 ± 16.28

97.65 ± 11.44

97.64 ± 11.03

 

heterozygous

232

91.86 ± 32.06

91.22 ± 22.23

94.48 ± 18.53

99.32 ± 10.57

99.80 ± 10.02

 

homozygous

64

92.61 ± 23.45

90.28 ± 17.19

97.32 ± 18.00

98.56 ± 10.75

98.16 ± 10.75

M+1

wild type

317

90.75 ± 30.97

89.70 ± 22.29

93.19 ± 17.82

98.17 ± 11.43*r

98.12 ± 11.05

 

heterozygous

128

91.28 ± 28.43

91.51 ± 22.15

95.56 ± 17.50

99.01 ± 9.86

99.86 ± 9.83

 

homozygous

4

109.34 ± 23.03

98.95 ± 12.38

95.75 ± 23.07

109.31 ± 9.13

105.89 ± 9.71

S1

wild type

359

90.57 ± 30.08

90.00 ± 21.74

93.23 ± 17.00*v

98.29 ± 10.86

98.46 ± 10.72

 

heterozygous

86

94.29 ± 31.08

92.01 ± 24.43

97.23 ± 21.03

99.63 ± 11.23

99.58 ± 10.02

 

homozygous

4

73.47 ± 16.07

76.17 ± 10.97

78.46 ± 11.72

90.84 ± 5.11

96.06 ± 1.40

S2

wild type

215

91.22 ± 31.50

89.69 ± 22.15

92.14 ± 17.03*d

97.50 ± 11.49*d

96.97 ± 11.32*v*d

 

heterozygous

202

91.30 ± 29.78

91.43 ± 22.16

96.12 ± 18.27

99.76 ± 10.73

100.55 ± 9.99

 

homozygous

31

95.31 ± 21.52

90.93 ± 22.04

94.54 ± 20.57

99.55 ± 9.27

98.70 ± 9.25

ST+4

wild type

158

90.05 ± 29.28

89.70 ± 22.41

93.18 ± 18.52

98.08 ± 10.38

99.09 ± 10.01

 

heterozygous

223

92.00 ± 29.50

91.32 ± 22.23

94.83 ± 18.14

99.06 ± 11.75

98.61 ± 11.11

 

homozygous

65

92.97 ± 34.91

90.22 ± 22.04

93.93 ± 14.12

98.68 ± 10.03

98.59 ± 11.39

ST+5

wild type

136

92.47 ± 31.51

91.10 ± 20.52

94.37 ± 15.25

99.26 ± 10.00

99.38 ± 10.88

 

heterozygous

236

91.87 ± 29.26

91.02 ± 23.37

94.65 ± 19.04

98.79 ± 11.61

98.62 ± 10.58

 

homozygous

88

87.50 ± 29.64

87.41 ± 20.55

91.39 ± 17.77

97.13 ± 10.41

98.48 ± 10.15

ST+7

wild type

285

90.28 ± 29.48

90.36 ± 21.92

93.30 ± 16.83

98.67 ± 10.93

99.10 ± 10.49

 

heterozygous

158

94.26 ± 31.56

91.07 ± 22.55

94.99 ± 19.60

98.98 ± 11.11

98.63 ± 10.92

 

homozygous

16

82.30 ± 24.76

82.94 ± 17.26

95.38 ± 16.31

93.87 ± 9.08

95.04 ± 7.62

T1

wild type

315

90.42 ± 31.04

89.55 ± 22.40

93.32 ± 17.78

98.07 ± 11.38

98.12 ± 10.83*d

 

heterozygous

135

92.59 ± 28.08

92.22 ± 21.39

95.50 ± 17.87

99.42 ± 9.78

100.10 ± 9.98

 

homozygous

8

98.09 ± 27.48

90.95 ± 23.47

91.61 ± 19.64

103.91 ± 11.37

103.30 ± 8.53

T2

wild type

317

90.60 ± 31.04

89.61 ± 22.34

93.37 ± 17.71

98.13 ± 11.36

98.14 ± 10.80*d

 

heterozygous

135

92.59 ± 28.08

92.22 ± 21.39

95.50 ± 17.87

99.42 ± 9.78

100.10 ± 9.98

 

homozygous

8

98.09 ± 27.48

90.95 ± 23.47

91.61 ± 19.64

103.91 ± 11.37

103.30 ± 8.53

V4

wild type

267

91.58 ± 30.15

89.98 ± 21.82

93.12 ± 17.14

98.24 ± 11.04

98.22 ± 10.82

 

heterozygous

163

89.70 ± 30.05

89.71 ± 22.19

94.63 ± 18.60

98.57 ± 10.65

99.20 ± 10.23

 

homozygous

26

95.52 ± 30.38

97.28 ± 24.60

96.90 ± 19.51

101.03 ± 11.93

99.82 ± 10.29

  1. *) significant differences (p < 0.05) in lung function parameters between genotypes are printed in bold letters,
  2. *v denotes significant differences in variance analysis,
  3. *d denotes significant differences in t-test for a dominant model,
  4. *r significant differences in t-test for a recessive model
  5. 1)N refers to the first lung function parameter. Minimal deviations of N in the other lung function parameters are possible.