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Figure 6 | Respiratory Research

Figure 6

From: Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells

Figure 6

Gelatin zymography of matrix-metalloproteinase (MMP) in conditioned medium from human PASMCs. Representative zymograms showing the effects of phorbol 12-myristate 13-acetate (PMA, 10-7 M) and 10 ng/ml TNF-α, IL-1β or TGF-β1 on inducible MMP-9 activity after 48 h (A) and the concentration-dependent inhibitory effect of cicaprost (B). MMP-9 (proMMP-9, 92 kDa); MMP-2 (proMMP-2, 72 kDa; active isoforms, 66 kDa and 62 kDa); MMP-2+, APMA-activated MMP-2; Dex, dexamethasone; Mif, mifepristone; 4α-PMA, inactive phorbol ester.

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