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Figure 2 | Respiratory Research

Figure 2

From: Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells

Figure 2

Characterisation of cAMP phosphodiesterase (PDE) activity in human PASMCs. Total cAMP hydrolytic activity and contribution of PDE enzyme families to cAMP hydrolysis in the cytosol (A) and membrane fractions (B) of human PASMCs (n = 5 isolates). Activity inhibited by 10-3} M EGTA (PDE1), 10-5 M EHNA (PDE2), 10-5 M cilostamide (PDE3) and 10-6 M roflumilast (PDE4).

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