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Table 4 Annual decline in FEV1 according to genotypes of TGF-β 1 and decorin. Changes in decline between genotypes in the total population and in subjects who developed COPD (GOLD stage II or higher; FEV1/VC<70%, FEV1<80% predicted) are presented.

From: Decorin and TGF-β 1 polymorphisms and development of COPD in a general population

   

Total population

COPD

Genotype

N

Decline in FEV 1 (ml/yr)*

ΔFEV 1 compared to WT

P value†

N

Decline in FEV 1 (ml/yr)*

ΔFEV 1 compared to WT

P value†

TGF-β 1

rs6957

AA

918

-19.2

  

103

-37.1

  
  

AG

399

-18.3

+0.9

0.511

71

-33.5

+3.6

0.297

  

GG

40

-18.2

+1.0

0.778

10

-28.8

+8.3

0.239

 

rs1800469

GG

716

-18.9

  

106

-34.3

  
  

GA

555

-17.6

+1.2

0.501

67

-36.2

-1.9

0.587

  

AA

103

-20.3

-1.5

0.437

10

-31.9

+2.4

0.698

 

rs1982073

GG

477

-19.1

  

75

-34.8

  
  

GA

623

-17.9

+1.2

0.309

72

+0.9

0.876

 
  

AA

185

-17.9

+1.2

0.593

23

-35.1

-0.3

0.959

Decorin

rs1803343

GG

1293

-18.7

  

173

-35.9

  
  

GA

85

-18.3

+0.4

0.874

13

-33.6

+2.3

0.698

 

rs11106030

CC

1206

-18.9

  

170

-35.2

  
  

CA

162

-19.6

-0.7

0.688

8

-38.3

-3.1

0.577

  

AA

6

-30.5

-11.6

0.285

1

-39.9

-4.7

0.797

 

rs741212

AA

1039

-18.6

  

131

-35.1

  
  

AG

198

-20.1

-1.5

0.287

43

-38.2

-3.1

0.439

  

GG

20

-14.1

+4.5

0.346

4

-23.2

+11.9

0.282

 

rs516115

AA

737

-18.8

  

102

-34.4

  
  

AG

519

-18.5

+0.3

0.814

65

-35.9

-1.5

0.669

  

GG

96

-18.9

+0.1

0.969

15

-35.0

-0.6

0.930

 

rs3138241

GG

1187

-18.8

  

136

-35.7

  
  

GA

157

-19.5

-0.7

0.694

10

-38.7

-3.0

0.588

  

AA

5

-25.7

-6.8

0.589

1

-31.6

+4.1

0.888

  1. Abbreviations: FEV1, forced expiratory volume in 1 second; TGF-β 1 , transforming growth factor-β1; COPD, Chronic Obstructive Pulmonary Disease; WT, wild-type
  2. *decline in FEV1 adjusted for gender, first FEV1 after age 30 years, pack-years, and age; † P value indicates significance of the effect of the genotype on decline in FEV1 compared to wild-type