From: Decorin and TGF-β 1 polymorphisms and development of COPD in a general population
Total population | COPD | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Genotype | N | Decline in FEV 1 (ml/yr)* | ΔFEV 1 compared to WT | P value† | N | Decline in FEV 1 (ml/yr)* | ΔFEV 1 compared to WT | P value† | ||
TGF-β 1 | rs6957 | AA | 918 | -19.2 | 103 | -37.1 | ||||
AG | 399 | -18.3 | +0.9 | 0.511 | 71 | -33.5 | +3.6 | 0.297 | ||
GG | 40 | -18.2 | +1.0 | 0.778 | 10 | -28.8 | +8.3 | 0.239 | ||
rs1800469 | GG | 716 | -18.9 | 106 | -34.3 | |||||
GA | 555 | -17.6 | +1.2 | 0.501 | 67 | -36.2 | -1.9 | 0.587 | ||
AA | 103 | -20.3 | -1.5 | 0.437 | 10 | -31.9 | +2.4 | 0.698 | ||
rs1982073 | GG | 477 | -19.1 | 75 | -34.8 | |||||
GA | 623 | -17.9 | +1.2 | 0.309 | 72 | +0.9 | 0.876 | |||
AA | 185 | -17.9 | +1.2 | 0.593 | 23 | -35.1 | -0.3 | 0.959 | ||
Decorin | rs1803343 | GG | 1293 | -18.7 | 173 | -35.9 | ||||
GA | 85 | -18.3 | +0.4 | 0.874 | 13 | -33.6 | +2.3 | 0.698 | ||
rs11106030 | CC | 1206 | -18.9 | 170 | -35.2 | |||||
CA | 162 | -19.6 | -0.7 | 0.688 | 8 | -38.3 | -3.1 | 0.577 | ||
AA | 6 | -30.5 | -11.6 | 0.285 | 1 | -39.9 | -4.7 | 0.797 | ||
rs741212 | AA | 1039 | -18.6 | 131 | -35.1 | |||||
AG | 198 | -20.1 | -1.5 | 0.287 | 43 | -38.2 | -3.1 | 0.439 | ||
GG | 20 | -14.1 | +4.5 | 0.346 | 4 | -23.2 | +11.9 | 0.282 | ||
rs516115 | AA | 737 | -18.8 | 102 | -34.4 | |||||
AG | 519 | -18.5 | +0.3 | 0.814 | 65 | -35.9 | -1.5 | 0.669 | ||
GG | 96 | -18.9 | +0.1 | 0.969 | 15 | -35.0 | -0.6 | 0.930 | ||
rs3138241 | GG | 1187 | -18.8 | 136 | -35.7 | |||||
GA | 157 | -19.5 | -0.7 | 0.694 | 10 | -38.7 | -3.0 | 0.588 | ||
AA | 5 | -25.7 | -6.8 | 0.589 | 1 | -31.6 | +4.1 | 0.888 |