Table 3 Prevalence of TGF-β 1 and decorin haplotypes in subjects with and without COPD (GOLD stage II or higher; FEV1/VC<70%, FEV1 <80% predicted).
From: Decorin and TGF-β 1 polymorphisms and development of COPD in a general population
Carrier of Haplotype* | |||||||
|---|---|---|---|---|---|---|---|
TGF-β 1 | rs1800469 | rs1982073 | rs6957 | No COPD N (%) | COPD N (%) | P value # | |
0 | 0 | 0 | 239 (23) | 34 (22) | 0.686 | ||
0 | 1 | 0 | 106 (11) | 11 (7.6) | 0.264 | ||
0 | 1 | 1 | 27 (3) | 6 (4) | 0.417 | ||
1 | 1 | 0 | 288 (29) | 31 (20) | 0.030 | ||
0 | 0 | 1 | 95 (9) | 25 (16) | 0.014 | ||
1 | 1 | 1 | 160 (16) | 34 (22) | 0.086 | ||
Decorin | rs3138241 | rs516115 | rs714212 | rs11106030 | No COPD N (%) | COPD N (%) | P value |
|---|---|---|---|---|---|---|---|
0 | 0 | 0 | 0 | 1009 (93) | 175 (92) | 0.515 | |
0 | 1 | 1 | 0 | 234 (22) | 47 (27) | 0.715 | |
1 | 1 | 0 | 1 | 133 (12) | 15 (9) | 0.950 |