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Table 1 Plasma amino acid levels (μM) in controls and CF patients before and after 14 days of i.v. antibiotic treatment for pulmonary exacerbation

From: Decreased systemic bioavailability of L-arginine in patients with cystic fibrosis

  

CF patients (n = 10)

 

Controls (n = 10)

before (% control)

after (% control)

P-value

L-arginine

67.7 ± 19.0

48.1 ± 19.9 (71) *

68.9 ± 19.5 (102)

0.02

L-ornithine

45.7 ± 13.8

56.6 ± 34.0 (124)

65.9 ± 15.5 (144)†

NS

L-citrulline

27.5 ± 8.8

28.3 ± 5.5 (103)

33.4 ± 5.8 (121)

NS

Threonine

128.1 ± 40.0

87.2 ± 30.7 (68) *

129.7 ± 50.4 (101)

0.01

Serine

97.7 ± 30.0

92.0 ± 26.3 (94)

92.9 ± 17.2 (95)

NS

Asparagine

52.5 ± 14.5

37.3 ± 12.4 (71) *

40.0 ± 11.0 (76)

NS

Glutamic Acid

18.6 ± 7.1

69.7 ± 40.7 (375) †

65.7 ± 52.5 (353)*

NS

Proline

170.3 ± 31.8

165.4 ± 43.2 (97)

216.8 ± 57.5 (127)*

NS

Glycine

205.1 ± 52.9

241.8 ± 100.6 (118)

323.5 ± 69.1 (158)†

0.02

Alanine

328.5 ± 73.6

243.1 ± 90.8 (74) *

355.3 ± 139.6 (108)

NS

Valine

203.0 ± 25.0

169.7 ± 32.1 (84) *

176.1 ± 39.6 (87)

NS

Cysteine

55.3 ± 15.6

30.1 ± 9.0 (54) †

42.4 ± 13.7 (77)

0.004

Methionine

24.9 ± 4.8

19.2 ± 5.2 (77) *

21.0 ± 5.6 (84)

NS

Isoleucine

57.6 ± 10.9

52.3 ± 18.1 (91)

62.9 ± 12.9 (109)

NS

Leucine

111.3 ± 22.2

90.4 ± 25.1 (81)

96.1 ± 23.9 (86)

NS

Tyrosine

54.7 ± 9.8

45.7 ± 14.3 (84)

44.7 ± 11.3 (82)

NS

Phenylalanine

49.9 ± 6.8

47.7 ± 10.7 (96)

49.0 ± 10.3 (98)

NS

Histidine

83.7 ± 7.2

55.9 ± 17.7 (67) †

64.4 ± 17.6 (77)†

NS

Tryptophan

49.8 ± 9.5

30.7 ± 15.8 (62) †

46.6 ± 11.7 (94)

0.02

Lysine

144.7 ± 42.5

144.0 ± 40.5 (100)

183.8 ± 51.9 (127)

NS

  1. Concentrations of amino acids are expressed in means ± SD. Symbols indicate significant differences of CF group to controls; *: p < 0.05, †: p ≤ 0.01. P-values shown are for comparison between CF groups before and after antibiotic treatment.