Table 2 Human studies investigating angiogenic and angiostatic parameters in patients with idiopathic interstitial pneumonias (1997–2003)
From: Angiogenesis in Interstitial Lung Diseases: a pathogenetic hallmark or a bystander?
Investigator (year) | Tissue samples Sample size | IIP | Studied Parameters | Summary | Limitations |
|---|---|---|---|---|---|
Keane et al. 41(1997) | Lung specimens/50 patients/54 controls | IPF | CXCL8, 10 | Increased levels of CXCL8,10 that favor angiogenesis | Incomplete analysis of the angiogenic network / In vivo micropocket assay |
Lappi-Blanco et al.53 (1999) | Lung specimens/19 patients | IPF-COP | VWF, CD34+ | Â | Small sample size / Lack of knowledge regarding factors responsible for vascular heterogeneity |
Meyer et al. 43 (2000) | BALF samples/32 patients/66 controls | IPF-CF-SARCO | VEGF | Decreased VEGF levels in IPF patients | Small number of patients / No correlation between serum and BALF levels / No correlation with clinical parameters of disease severity |
Keane et al. 42 (2001) | Lung specimens/91 patients/78 controls | IPF | CXCL5 | Increased CXCL5 levels in IPF patients | Incomplete analysis of the angiogenic network |
Lappi-Blanco et al. 54(2002) | Lung specimens/19 patients | IPF-COP | VEGF, bFGF | Increased VEGF and bFGF levels in MB compared to FF | Small sample size / Lack of knowledge regarding angiostatic regulators |
Koyama et al. 44 (2002) | BALF samples/49 patients/27controls | IPF-PF/CTD-SARCO | VEGF | Decreased VEGF levels in IPF patients | High variability between serum and BALF levels in health and disease |
Renzoni et al. 45 (2003) | Lung specimens/17 patients/12 controls | CFA-SSc | Vascular density and distribution | Abnormal vascular distribution in areas proximal to gas exchange / Phenotypically altered vessels | Morphometric study not suitable to identify the role of angiogenesis in hypoxemia |