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Table 2 Studies showing an association between bacterial infections and airway inflammation in stable COPD and on exacerbations

From: Novel insights into the aetiology and pathophysiology of increased airway inflammation during COPD exacerbations

Year

Author

Main finding

1999

Soler

Increased NEU, TNF-a in colonized pts

2000

Bresser

Increased TNF-a, MPO, IL-8 in H. Influenzae colonized pts

2000

Hill

Positive relation between MPO, NE, IL8, LTB4 and bacterial load in stable state. Increased MPO and decreased SLPI in Ps. Aeroginosa colonized pts

2000

Sethi

Increased TNFa, NE in H. Influenae and M. Catarrhalis exacerbations

2000

Crooks

Decrease in MPO, IL8, LTB4, after treatment of bacterial exacerbations

2001

Gombertz

Decrease in LTB4 after treatment of purulent exacerbations

2002

Patel

Positive relation between IL8 and bacterial load. Decreased SLPI in colonized pts

2003

White

Decrease in LTB4, increase in SLPI after bacteria eradication on exacerbations