Figure 1

Study design for Ad5 infection and allergic inflammation in Cam Hartley Guinea pigs Animal model as modified from [12]. Animals were Ad5 infected or sham treated. In Acute model animals were sacrificed at d1–d7 post-infection. Other Ad5 infected or Sham treated animals were supported for 3 weeks post-infection (Chronic model). These Guinea pigs were then sensitized with OVA by aerosol administration at day 0 (◆) followed by aerosol challenges as indicated (*). Steroids were given to a subset of these Guinea pigs at the indicated days (•) to permit resolution of the OVA-induced inflammation