Polymorphism

Genotype

Physician visits‡§

Part 1 p Value*

Part 2 p Value†

Days in bed‡ll

Part 1 p Value*

Part 2 p Value†


DEFA1/DEFA3
       

DEFA1 only

0.22 (0.07)

0.23

0.05

0.38 (0.16)

0.60

0.36


DEFA1/DEFA3

0.28 (0.02)
  
0.51 (0.06)
  
DEFB1 G20A
       

GG

0.27 (0.04)

0.85

0.88

0.49 (0.10)

0.86

0.98


GA

0.26 (0.03)
  
0.48 (0.08)
  

AA

0.30 (0.05)
  
0.54 (0.11)
  
DEFB1 C44G
       

CC

0.28 (0.03)

0.81

0.42

0.53 (0.07)

0.93

0.14


CG

0.27 (0.04)
  
0.44 (0.10)
  

GG

0.18 (0.10)
  
0.28 (0.24)
  
DEFB1 G52A
       

GG

0.29 (0.04)

0.67

0.62

0.47 (0.08)

0.81

0.29


GA

0.25 (0.03)
  
0.47 (0.08)
  

AA

0.30 (0.06)
  
0.62 (0.14)
  
 Definition of abbreviations: DEFA = alphadefensin; DEFB = betadefensin.
 *Part 1 of the twopart model involves modeling whether an individual has any physician visits or any days in bed due to lower respiratory infection. P values for global haplotype association derived from logistic regression analysis. Decline in lung function status was included as a factor in the analysis.
 †Part 2 of the twopart model involves modeling the average number of physician visits or days in bed due to lower respiratory infection given that it is greater than zero. P values for global haplotype association derived from gamma regression analysis. Decline in lung function status was included as a factor in the analysis.
 ‡Mean (SE).
 §Mean number of visits to a physician for lower respiratory infections per year.
 llMean number of days kept in bed for lower respiratory infections per year.