Polymorphism | Genotype | Physician visits‡§ | Part 1 p Value* | Part 2 p Value†| Days in bed‡ll | Part 1 p Value* | Part 2 p Value†|
|---|
DEFA1/DEFA3 | Â | Â | Â | Â | Â | Â | Â |
| Â | DEFA1 only | 0.22 (0.07) | 0.23 | 0.05 | 0.38 (0.16) | 0.60 | 0.36 |
| Â | DEFA1/DEFA3 | 0.28 (0.02) | Â | Â | 0.51 (0.06) | Â | Â |
DEFB1 G-20A | Â | Â | Â | Â | Â | Â | Â |
| Â | GG | 0.27 (0.04) | 0.85 | 0.88 | 0.49 (0.10) | 0.86 | 0.98 |
| Â | GA | 0.26 (0.03) | Â | Â | 0.48 (0.08) | Â | Â |
| Â | AA | 0.30 (0.05) | Â | Â | 0.54 (0.11) | Â | Â |
DEFB1 C-44G | Â | Â | Â | Â | Â | Â | Â |
| Â | CC | 0.28 (0.03) | 0.81 | 0.42 | 0.53 (0.07) | 0.93 | 0.14 |
| Â | CG | 0.27 (0.04) | Â | Â | 0.44 (0.10) | Â | Â |
| Â | GG | 0.18 (0.10) | Â | Â | 0.28 (0.24) | Â | Â |
DEFB1 G-52A | Â | Â | Â | Â | Â | Â | Â |
| Â | GG | 0.29 (0.04) | 0.67 | 0.62 | 0.47 (0.08) | 0.81 | 0.29 |
| Â | GA | 0.25 (0.03) | Â | Â | 0.47 (0.08) | Â | Â |
| Â | AA | 0.30 (0.06) | Â | Â | 0.62 (0.14) | Â | Â |
- Definition of abbreviations: DEFA = alpha-defensin; DEFB = beta-defensin.
- *Part 1 of the two-part model involves modeling whether an individual has any physician visits or any days in bed due to lower respiratory infection. P values for global haplotype association derived from logistic regression analysis. Decline in lung function status was included as a factor in the analysis.
- †Part 2 of the two-part model involves modeling the average number of physician visits or days in bed due to lower respiratory infection given that it is greater than zero. P values for global haplotype association derived from gamma regression analysis. Decline in lung function status was included as a factor in the analysis.
- ‡Mean (SE).
- §Mean number of visits to a physician for lower respiratory infections per year.
- llMean number of days kept in bed for lower respiratory infections per year.
