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Figure 2 | Respiratory Research

Figure 2

From: Effects of overexpression of IL-10, IL-12, TGF-β and IL-4 on allergen induced change in bronchial responsiveness

Figure 2

Effect of different cytokine genes on methacholine- induced increases in airway hyperresponsiveness (AHR). Mice were treated as described in Figure 1. One day after the last OVA challenge, AHR was measured in response to increasing concentrations of methacholine (0–50 mg/ml) in conscious mice placed in a whole-body plethysmograph. "Negative control" mice were mice that were sensitized and challenged with normal saline. Both "positive control" mice and "vector-only" mice were mice that immunized and challenged with OVA. However, only the "vector-only" group was treated with mock DNA plasmid. Data are representative of three separate experiments with similar results. The columns and error bars represent mean ± SEM for each group. * P < 0.05, ** P <0.01 as compared with the vector-only treated control group

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