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Table 3 Minimal Clinically Important Difference (MCID) for the Clinical COPD Questionnaire (CCQ) by criterion referencing. Differences between baseline (Day 42) CCQ scores are grouped according to major health events during 12-month follow-up. Unpaired-sample t-tests were used for total CCQ scores and for symptom and functional domains, with equal variances assumed; the Mann-Whitney U test was used for the mental domain.

From: Health status measurement in COPD: the minimal clinically important difference of the clinical COPD questionnaire

CCQ score category Score difference
  Mean 95% confidence interval p value
Death (n = 25) or survival (n = 143)    
Total -0.80 -1.23, -0.37 <0.001*
Symptoms -0.62 -1.13, -0.12 0.015*
Function -1.32 -1.90, -0.74 <0.001*
Mental 0.5§   0.211
Rehospitalization (n = 56) or not (n = 112)    
Total -0.18 -0.52, 0.16 0.290
Symptoms -0.07 -0.46–0.31 0.706
Function -0.47 -0.93, -0.007 0.047*
Mental   0.505
Death/rehospitalization (n = 70) versus survival/no rehospitalization (n = 98)    
Total -0.39 -0.71, -0.07 0.017*
Symptoms -0.27 -0.63, 0.10 0.153
Function -0.77 -1.19, -0.34 0.001*
Mental   0.987
  1. * Statistically significant (2-tailed): p < 0.05. § Difference in median scores
  2. COPD = chronic obstructive pulmonary disease.