Figure 2

Role of arginase and NO in impaired iNANC nerve-induced relaxation of guinea pig tracheal smooth muscle after allergen-challenge. Electrical field stimulation-induced relaxation of precontracted tracheal open-ring preparations obtained from unchallenged and from OA-challenged guinea pigs in the absence and presence of the arginase inhibitor nor-NOHA (10 μM), with or without the NOS inhibitor L-NNA (100 μM). Results are means ± s.e.m. of 7 experiments for each condition. *P < 0.05 and **P < 0.01 compared to unchallenged control, ^†P < 0.05 and ^‡P < 0.01 compared to OA-challenged control, ^#P < 0.01 compared to nor-NOHA-treated.