Figure 1

iNANC nerve-induced airway smooth muscle relaxation is impaired after allergen challenge due to deficiency of nNOS-derived NO. Electrical field stimulation-induced relaxation of precontracted tracheal open-ring preparations obtained from unchallenged and from OA-challenged guinea pigs in the absence and presence of the NOS inhibitor L-NNA (100 μM). Results are means ± s.e.m. of 7 experiments for each condition. *P < 0.05 and **P < 0.01 compared to unchallenged control, n.s. = non significant.