Figure 7
From: Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice
Airway responsiveness (expressed as Penh) to aerosolized methacholine was measured in conscious, unrestrained mice 24 hours after challenge. Increased airway responsiveness to methacholine (p < 0.01) was observed in OVA/WT mice (black bar, n = 7) compared to SAL/WT mice (white bar, n = 9). No effect on airway responsiveness was observed in SAL/eNOS mice (hatched bar, n = 7). Airway hyperresponsiveness was abolished in OVA/eNOS mice (grey bar, n = 11) compared to OVA/WT mice (p < 0.05 at 25 mg/ml methacholine). Data are presented as mean ± SEM. # p < 0.05 compared to OVA/WT mice.