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Table 3 Association between CD4 cell count and IFN-γ release in response to PHA.

From: Latent Tuberculosis in HIV positive, diagnosed by the M. Tuberculosis Specific Interferon-γ test

CD4 cell counts1)

No of patients

Number and percentage of PHA non-responders

IFN-γ release (Median and 25–75 percentile)

<100

17

4 (24%)*

1,53 (0,34-19,49)#

100–199

37

1 (3%)

11.58 (3,88-30,11)

200–299

63

5 (8%)

16,78 (9,40-25,20)

>300

473

10 (2%)

20,35 (13,20–31,00)

  1. 1) cells/μl
  2. * p < 0.0005, difference in the proportion of PHA-non-responders between patients with a CD4 cell count higher or lower than 100 cells/μL (Chi-Square test).
  3. # p = 0.0001 difference in the median IFN-γ release between patients with a CD4 cell count < 100 compared to groups of patients with a CD4 cell count ≥ 100 cells/μL (Mann-Withney U test) and there was a trend for increasing INF-γ release for increasing CD4 group (non-parametric test for trend across ordered groups (p < 0.0001).
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Respiratory Research

ISSN: 1465-993X

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