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Table 3 Association between CD4 cell count and IFN-γ release in response to PHA.

From: Latent Tuberculosis in HIV positive, diagnosed by the M. Tuberculosis Specific Interferon-γ test

CD4 cell counts1) No of patients Number and percentage of PHA non-responders IFN-γ release (Median and 25–75 percentile)
<100 17 4 (24%)* 1,53 (0,34-19,49)#
100–199 37 1 (3%) 11.58 (3,88-30,11)
200–299 63 5 (8%) 16,78 (9,40-25,20)
>300 473 10 (2%) 20,35 (13,20–31,00)
  1. 1) cells/μl
  2. * p < 0.0005, difference in the proportion of PHA-non-responders between patients with a CD4 cell count higher or lower than 100 cells/μL (Chi-Square test).
  3. # p = 0.0001 difference in the median IFN-γ release between patients with a CD4 cell count < 100 compared to groups of patients with a CD4 cell count ≥ 100 cells/μL (Mann-Withney U test) and there was a trend for increasing INF-γ release for increasing CD4 group (non-parametric test for trend across ordered groups (p < 0.0001).