Table 1 Demographic and Medical Data
From: Cognitive, emotional, and quality of life outcomes in patients with pulmonary arterial hypertension
| Â | Total Group (N = 46) | Cognitive Sequelae (N = 27) | No Cognitive Sequelae (N = 19) | Cognitive Sequelae vs. No Cognitive Sequelae P value |
|---|---|---|---|---|
Gender Female N (%) | 38 (82.6%) | 23 (60.5%) | 14 (39.5%) | 0.43 |
Age in years M ± SD (range) | 48.2 ± 11.8 (20 to 69) | 48.6 ± 11.8 (24 to 69) | 47.6 ± 12 (20 to 65) | 0.78 |
Education in years M ± SD (range) | 13.6 ± 3.0 (4 to 8) | 13.3 ± 3.3 (4 to 18) | 14.1 ± 2.4 (11 to18) | 0.37 |
Time from PAH Diagnosis to testing in years M ± SD (range) | 2.6 ± 2.6 (0.08 to 11.9) | 2.0 ± 1.4 (0.08 to 5.2) | 3.4 ± 3.5 (0.08–11.9) | 0.07 |
New York Heart Classification: N (%) | Â | Â | Â | Â |
Class I | 2 (4.3) | 2 | 0 | 0.17 |
Class II | 9 (19.6) | 5 | 4 | 0.47 |
Class III | 34 (67.4) | 11 | 23 | 0.10 |
Class IV | 1 (2.2) | 0 | 1 | 0.99 |
Etiology of PAH: N (%) | Â | Â | Â | Â |
Drug/Toxin | 16 (34.8) | 6 | 10 | 0.77 |
Primary Pulmonary Hypertension | 19 (40) | 10 | 9 | 0.23 |
Collagen Vascular Disease | 8 (17.4) | 3 | 5 | 0.82 |
Portal Hypertension | 2 (4.3) | 0 | 2 | 0.50 |
Congenital systemic-to- pulmonary shunt | 1 (2.2) | 0 | 1 | 0.50 |
Medications: N (%) | Â | Â | Â | Â |
Vasodilators | 25 (54.3) | 9 | 16 | 0.32 |
Calcium Channel Blockers | 16 (34.8) | 9 | 7 | 0.13 |
Endothelial Receptor Antagonists | 15 (32.6) | 6 | 9 | 0.59 |
Anticoagulants | 30 (65.2) | 13 | 17 | 0.48 |
Prostacyclins | Â | Â | Â | Â |
Epoprostenol | 12 (25.5) | 6 | 6 | 0.48 |
Treprostinil | 16 (34.8) | 10 | 6 | 0.71 |
Supplemental Oxygen: N (%) | 30 (65.2) | 10 | 20 | 0.11 |
Oxygen Daytime: liters/minute | 2.84 | 3.0 | 2.6 | 0.54 |
Oxygen Night: liters/minute | 2.90 | 2.9 | 2.8 | 0.84 |
Medical Variables M ± SD |  |  |  |  |
PaO2 | Â | Â | Â | Â |
Diagnostic | 63.7 ± 12.5 | 62.2 ± 15 | 65.6 ± 8.0 | 0.39 |
Most Recent (N = 30) | 68.0 ± 9.8 | 66.3 ± 10 | 70.4 ± 9.3 | 0.27 |
Mean Right Atrial Pressure (mmHg) | Â | Â | Â | Â |
Diagnostic | 12.1 ± 6.9 | 11.4 ± 5.7 | 13.0 ± 8.5 | 0.45 |
Most Recent (N = 34) | 11.0 ± 5.4 | 10.9 ± 5.6 | 11.1 ± 5.1 | 0.92 |
Mean Pulmonary Capillary Wedge Pressure (mmHg) | Â | Â | Â | Â |
Diagnostic | 11.4 ± 4.5 | 11.6 ± 4.8 | 11.1 ± 4.1 | 0.75 |
Most Recent (N = 33) | 11.2 ± 5.3 | 11.4 ± 5.5 | 10.9 ± 5 | 0.79 |
Mean Pulmonary Artery Pressure (mmHg) | Â | Â | Â | Â |
Diagnostic | 53.6 ± 13.9 | 52.1 ± 13.1 | 55.5 ± 15.2 | 0.42 |
Most Recent (N = 34) | 52.7 ± 13.5 | 55.6 ± 13.7 | 48.8 ± 12.5 | 0.15 |
Mean Cardiac Output (thermo; L/min) | Â | Â | Â | Â |
Diagnostic | 4.4 ± 1.8 | 4.2 ± 1.8 | 4.6 ± 1.8 | 0.48 |
Most Recent (N = 31) | 4.5 ± 1.6 | 4.4 ± 1.5 | 4.5 ± 1.8 | 0.87 |
Mean Cardiac Index (thermo; L/min) | Â | Â | Â | Â |
Diagnostic | 2.4 ± 0.8 | 2.2 ± 0.7 | 2.6 ± 0.7 | 0.27 |
Most Recent (N = 10) | 2.4 ± 0.5 | 2.7 ± 0.4 | 2.2 ± 0.3 | 0.06 |
Pulmonary Vascular Resistance (Woods unit) | Â | Â | Â | Â |
Diagnostic | 11.4 ± 5.2 | 11.6 ± 5 | 11.1 ± 5.4 | 0.77 |
Most Recent (N = 30) | 11.1 ± 6.1 | 11.6 ± 6.6 | 10.4 ± 5.6 | 0.58 |